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School of Medicine

Physiology

Publications-Adjunct, Associate, and Joint Faculty

January-December -  2016

M. Safwan Badr, M.D.
Wayne State University
Dept. Internal Medicine
Division of Pulmonary & Critical Care

  1. Chowdhuri S, Badr MS. Control of Ventilation in Health and Disease. Chest. 2016 Dec 19. pii: S0012-3692(16)62589-8. doi: 10.1016/j.chest.2016.12.002. Review. PMID: 28007622
  2. Lozo T, Komnenov D, Badr MS, Mateika JH. Sex differences in sleep disordered breathing in adults. Respir Physiol Neurobiol. 2016 Nov 9. pii: S1569-9048(16)30222-1. doi: 10.1016/j.resp.2016.11.001. Review. PMID: 27836648
  3. Sankari A, Pranathiageswaran S, Maresh S, Hosni AM, Badr MS. Characteristics and Consequences of Non-apneic Respiratory Events during Sleep. Sleep. 2016 Sep 26. pii: sp-00391-16. PMID: 27692057
  4. Bascom AT, Sankari A, Badr MS. Spinal cord injury is associated with enhanced peripheral chemoreflex sensitivity. Physiol Rep. 2016 Sep;4(17). pii: e12948. doi: 10.14814/phy2.12948. PMID: 27597767
  5. Badr MS, Attia SS, El-Sherbiny WS, Abd-Allah M A el E, Hefny HM, Salem AN. GENETIC POLYMORPHISM OF TOXOPLASMA GONDII FROM RECENTLY INFECTED ABORTED EGYPTIAN WOMEN. J Egypt Soc Parasitol. 2016 Apr;46(1):49-55. PMID: 27363040
  6. Shafazand S, Badr MS. Adaptive Servo-Ventilation and Central Apnea Associated with Systolic Heart Failure. J Clin Sleep Med. 2016 Jan;12(1):147-50. doi: 10.5664/jcsm.5420. PMID: 26888594
  7. Sankari A, Badr MS. Diagnosis of Sleep Disordered Breathing in Patients With Chronic Spinal Cord Injury. Arch Phys Med Rehabil. 2016 Jan;97(1):176-7. doi: 10.1016/j.apmr.2015.10.085. PMID: 26710861
  8. Alchakaki A, Riehani A, Shikh-Hamdon M, Mina N, Badr MS, Sankari A. Expiratory Snoring Predicts Obstructive Pulmonary Disease in Patients with Sleep-disordered Breathing. Ann Am Thorac Soc. 2016 Jan;13(1):86-92. doi: 10.1513/AnnalsATS.201507-413OC. PMID: 26630563
  9. Woodson BT, Soose RJ, Gillespie MB, Strohl KP, Maurer JT, de Vries N, Steward DL, Baskin JZ, Badr MS, Lin HS, Padhya TA, Mickelson S, Anderson WM, Vanderveken OM, Strollo PJ Jr; STAR Trial Investigators.. Three-Year Outcomes of Cranial Nerve Stimulation for Obstructive Sleep Apnea: The STAR Trial. Otolaryngol Head Neck Surg. 2016 Jan;154(1):181-8. doi: 10.1177/0194599815616618. PMID: 26577774
  10. Soose RJ, Woodson BT, Gillespie MB, Maurer JT, de Vries N, Steward DL, Strohl KP, Baskin JZ, Padhya TA, Badr MS, Lin HS, Vanderveken OM, Mickelson S, Chasens E, Strollo PJ Jr; STAR Trial Investigators. Upper Airway Stimulation for Obstructive Sleep Apnea: Self-Reported Outcomes at 24 Months. J Clin Sleep Med. 2016 Jan;12(1):43-8. doi: 10.5664/jcsm.5390. PMID: 26235

William Beierwaltes, Ph.D.
Henry Ford Hospital
Division of Hypertension and Vascular Research

  1. Gordish KL, Beierwaltes WH. Chronic resveratrol reverses a mild angiotensin II-induced pressor effect in a rat model. Integr Blood Press Control. 2016 Jan 28;9:23-31. doi: 10.2147/IBPC.S96092. eCollection 2016.

Walter Boron, M.D., Ph.D.
Case Western Reserve University
Department of Physiology and Biophysics

  1. Zhou Y, Skelton LA, Xu L, Chandler MP, Berthiaume JM, Boron WF. Role of Receptor Protein Tyrosine Phosphatase γ in Sensing Extracellular CO2 and HCO3. J Am Soc Nephrol. 2016 Sep;27(9):2616-21. doi: 10.1681/ASN.2015040439. PMID: 26839367
  2. Wang C, Hu H, Qin X, Zeise B, Xu D, Rappel WJ, Boron WF, Schroeder JI. Reconstitution of CO2 Regulation of SLAC1 Anion Channel and Function of CO2-Permeable PIP2;1 Aquaporin as CARBONIC ANHYDRASE4 Interactor. Plant Cell. 2016 Feb;28(2):568-82. doi: 10.1105/tpc.15.00637. PMID: 26764375
  3. Boedtkjer E, Hansen KB, Boedtkjer DM, Aalkjaer C, Boron WF. Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ. J Cereb Blood Flow Metab. 2016 May;36(5):965-80. doi: 10.1177/0271678X15610787. PMID: 26661205

Barry Franklin, Ph.D.
William Beaumont Hospital
Cardiac Rehabilitation Program and Exercise Laboratories

  1. de Souza E Silva CG, Franklin BA, de Araújo CG. Influence of central obesity in estimating maximal oxygen uptake. Clinics (Sao Paulo). 2016 Nov 1;71(11):629-634. doi: 10.6061/clinics/2016(11)02. PMID: 27982162
  2. Chaddha A, Jackson EA, Richardson CR, Franklin BA. Technology to Help Promote Physical Activity. Am J Cardiol. 2017 Jan 1;119(1):149-152. doi: 10.1016/j.amjcard.2016.09.025. PMID: 27889045
  3. Ross R, Blair SN, Arena R, Church TS, Després JP, Franklin BA, Haskell WL, Kaminsky LA, Levine BD, Lavie CJ, Myers J, Niebauer J, Sallis R, Sawada SS, Sui X, Wisløff U; American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health.; Council on Clinical Cardiology.; Council on Epidemiology and Prevention.; Council on Cardiovascular and Stroke Nursing.; Council on Functional Genomics and Translational Biology.; Stroke Council. Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement From the American Heart Association. Circulation. 2016 Dec 13;134(24):e653-e699. PMID: 27881567
  4. Franklin BA, Berra K, Lavie CJ. Should I Have an Exercise Stress Test? JAMA Cardiol. 2016 Dec 1;1(9):1084. doi: 10.1001/jamacardio.2016.3761. No abstract available.  PMID: 27806169
  5. Jae SY, Franklin BA, Schmidt-Trucksass A, Kim DK, Choi YH, Park JB. Relation of Cardiorespiratory Fitness to Risk of Subclinical Atherosclerosis in Men With Cardiometabolic Syndrome. Am J Cardiol. 2016 Nov 1;118(9):1282-1286. doi: 10.1016/j.amjcard.2016.07.064. PMID: 27600458
  6. Jae SY, Kurl S, Franklin BA, Laukkanen JA. Changes in cardiorespiratory fitness predict incident hypertension: A population-based long-term study. Am J Hum Biol. 2016 Oct 18. doi: 10.1002/ajhb.22932. PMID: 27753165
  7. Nagle EF, Sanders ME, Gibbs BB, Franklin BA, Nagle JA, Prins PJ, Johnson CD, Robertson RJ. Reliability and Accuracy of a Standardized Shallow Water Running Test to Determine Cardiorespiratory Fitness. J Strength Cond Res. 2016 Sep 16. PMID: 27669180
  8. Sagner M, Binks M, Yapijakis C, Lavie CJ, Frank E, Franklin BA, Forman DE, Arena R, La Vecchia C, Puska P. Overcoming Potential Threats to Scientific Advancements: Conflict of Interest, Ulterior Motives, False Innuendos and Harassment. Prog Cardiovasc Dis. 2016 Jul 19. pii: S0033-0620(16)30055-X. doi: 10.1016/j.pcad.2016.07.003. PMID: 27450511
  9. Sallis RE, Baggish AL, Franklin BA, Whitehead JR. The Call for a Physical Activity Vital Sign in Clinical Practice. Am J Med. 2016 Sep;129(9):903-5. doi: 10.1016/j.amjmed.2016.05.005. PMID: 27235007
  10. Sallis RE, Matuszak JM, Baggish AL, Franklin BA, Chodzko-Zajko W, Fletcher BJ, Gregory A, Joy E, Matheson G, McBride P, Puffer JC, Trilk J, Williams J. Call to Action on Making Physical Activity Assessment and Prescription a Medical Standard of Care. Curr Sports Med Rep. 2016 May-Jun;15(3):207-14. doi: 10.1249/JSR.0000000000000249. PMID: 27172086
  11. de Souza E Silva CG, Franklin BA, Forman DE, Araújo CG. Influence of age in estimating maximal oxygen uptake. J Geriatr Cardiol. 2016 Feb;13(2):126-31. doi: 10.11909/j.issn.1671-5411.2016.02.010. PMID: 27168737
  12. Jae SY, Bunsawat K, Fadel PJ, Fernhall B, Choi YH, Park JB, Franklin BA. Attenuated Heart Rate Recovery After Exercise Testing and Risk of Incident Hypertension in Men. Am J Hypertens. 2016 Sep;29(9):1103-8. doi: 10.1093/ajh/hpw028. PMID: 27037713
  13. Franklin BA. Invited Commentary: Simulated performance testing to determine the aortic dissection patient's potential for vigorous physical activity. Proc (Bayl Univ Med Cent). 2016 Apr;29(2):154-6. PMID: 27034551
  14. Varghese T, Schultz WM, McCue AA, Lambert CT, Sandesara PB, Eapen DJ, Gordon NF, Franklin BA, Sperling LS. Physical activity in the prevention of coronary heart disease: implications for the clinician. Heart. 2016 Jun 15;102(12):904-9. doi: 10.1136/heartjnl-2015-308773. Review. PMID: 26941396
  15. Jae SY, Kurl S, Laukkanen JA, Zaccardi F, Choi YH, Fernhall B, Carnethon M, Franklin BA. Exercise Heart Rate Reserve and Recovery as Predictors of Incident Type 2 Diabetes. Am J Med. 2016 May;129(5):536.e7-536.e12. doi: 10.1016/j.amjmed.2016.01.014. PMID: 26844636
  16. Lavie CJ, Arena R, Franklin BA. Cardiac Rehabilitation and Healthy Life-Style Interventions: Rectifying Program Deficiencies to Improve Patient Outcomes. J Am Coll Cardiol. 2016 Jan 5;67(1):13-5. doi: 10.1016/j.jacc.2015.09.103. PMID: 26764060
  17. Jae SY, Franklin BA, Choo J, Yoon ES, Choi YH, Park WH. Fitness, Body Habitus, and the Risk of Incident Type 2 Diabetes Mellitus in Korean Men. Am J Cardiol. 2016 Feb 15;117(4):585-9. doi: 10.1016/j.amjcard.2015.11.046. PMID: 26721657
  18. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH, O'Gara PT, Kushner FG, Ascheim DD, Brindis RG, Casey DE Jr, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. J Am Coll Cardiol. 2016 Mar 15;67(10):1235-50. doi: 10.1016/j.jacc.2015.10.005. Review. No abstract available. Erratum in: J Am Coll Cardiol. 2016 Mar 29;67(12):1506. PMID: 26498666
  19. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH, O'Gara PT, Kushner FG, Ascheim DD, Brindis RG, Casey DE Jr, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation. 2016 Mar 15;133(11):1135-47. doi: 10.1161/CIR.0000000000000336. Erratum in: Circulation. 2016 Mar 15;133(11):e442-3. PMID: 26490017
  20. Endorsed by the Latin American Society of Interventional Cardiology.; PCI WRITING COMMITTEE., Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Ting HH; STEMI WRITING COMMITTEE., O'Gara PT, Kushner FG, Ascheim DD, Brindis RG, Casey DE Jr, Chung MK, de Lemos JA, Diercks DB, Fang JC, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Kristin Newby L, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Joseph Woo Y, Zhao DX; ACC/AHA TASK FORCE MEMBERS., Halperin JL, Levine GN, Anderson JL, Albert NM, Al-Khatib SM, Birtcher KK, Bozkurt B, Brindis RG, Cigarroa JE, Curtis LH, Fleisher LA, Gentile F, Gidding S, Hlatky MA, Ikonomidis J, Joglar J, Kovacs RJ, Magnus Ohman E, Pressler SJ, Sellke FW, Shen WK, Wijeysundera DN. 2015 ACC/AHA/SCAI focused update on primary percutaneous coronary intervention for patients with ST-elevation myocardial Infarction: An update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention and the 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Catheter Cardiovasc Interv. 2016 May;87(6):1001-19. doi: 10.1002/ccd.26325. PMID: 26489034

Pam Harding, Ph.D.
Henry Ford Hospital
Division of Hypertension and Vascular Research

  1. Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, Harding P. Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Circ Heart Fail. 2016 Aug;9(8). pii: e003291. doi: 10.1161/CIRCHEARTFAILURE.116.003291. PMID: 27502370
  2. Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, Carretero OA. Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1176-83. doi: 10.1152/ajpheart.00252.2015. PMID: 26945075 1

Steve Keteyian, Ph.D.
Henry Ford Hospital
Preventative Cardiology

  1. Keteyian SJ, Kerrigan DJ, Ehrman JK, Brawner CA. Exercise Training Workloads Upon Exit From Cardiac Rehabilitation in Men and Women: THE HENRY FORD HOSPITAL EXPERIENCE. J Cardiopulm Rehabil Prev. 2016 Oct 14. PMID: 27755258
  2. Al Rifai M, Patel J, Hung RK, Nasir K, Keteyian SJ, Brawner CA, Ehrman JK, Sakr S, Blumenthal RS, Blaha MJ, Al-Mallah MH. Higher Fitness Is Strongly Protective in Patients with Family History of Heart Disease: The FIT Project. Am J Med. 2017 Mar;130(3):367-371. doi: 10.1016/j.amjmed.2016.09.026. PMID: 27751899
  3. Hung RK, Al-Mallah MH, Whelton SP, Michos ED, Blumenthal RS, Ehrman JK, Brawner CA, Keteyian SJ, Blaha MJ. Effect of Beta-Blocker Therapy, Maximal Heart Rate, and Exercise Capacity During Stress Testing on Long-Term Survival (from The Henry Ford Exercise Testing Project). Am J Cardiol. 2016 Dec 1;118(11):1751-1757. doi: 10.1016/j.amjcard.2016.08.060. PMID: 27670797
  4. Parikh KS, Coles A, Schulte PJ, Kraus WE, Fleg JL, Keteyian SJ, Piña IL, Fiuzat M, Whellan DJ, O'Connor CM, Mentz RJ. Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).Am J Cardiol. 2016 Oct 15;118(8):1211-1216. doi: 10.1016/j.amjcard.2016.07.040. PMID: 27561194
  5. Kelly JP, Dunning A, Schulte PJ, Fiuzat M, Leifer ES, Fleg JL, Cooper LS, Keteyian SJ, Kitzman DW, Pina IL, Kraus WE, Whellan DJ, O'Connor CM, Mentz RJ. Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION. JACC Heart Fail. 2016 Aug;4(8):617-24. doi: 10.1016/j.jchf.2016.05.006. PMID: 27395348
  6. Kim J, Al-Mallah M, Juraschek SP, Brawner C, Keteyian SJ, Nasir K, Dardari ZA, Blumenthal RS, Blaha MJ. The association of clinical indication for exercise stress testing with all-cause mortality: the FIT Project. Arch Med Sci. 2016 Apr 1;12(2):303-9. doi: 10.5114/aoms.2016.59255. PMID: 27186173
  7. Al-Mallah MH, Juraschek SP, Whelton S, Dardari ZA, Ehrman JK, Michos ED, Blumenthal RS, Nasir K, Qureshi WT, Brawner CA, Keteyian SJ, Blaha MJ. Sex Differences in Cardiorespiratory Fitness and All-Cause Mortality: The Henry Ford ExercIse Testing (FIT) Project. Mayo Clin Proc. 2016 Jun;91(6):755-62. doi: 10.1016/j.mayocp.2016.04.002. PMID: 27161032
  8. McAuley PA, Blaha MJ, Keteyian SJ, Brawner CA, Al Rifai M, Dardari ZA, Ehrman JK, Al-Mallah MH. Fitness, Fatness, and Mortality: The FIT (Henry Ford Exercise Testing) Project. Am J Med. 2016 Sep;129(9):960-965.e1. doi: 10.1016/j.amjmed.2016.04.007. PMID: 27154778
  9. Michler RE, Smith PK, Parides MK, Ailawadi G, Thourani V, Moskowitz AJ, Acker MA, Hung JW, Chang HL, Perrault LP, Gillinov AM, Argenziano M, Bagiella E, Overbey JR, Moquete EG, Gupta LN, Miller MA, Taddei-Peters WC, Jeffries N, Weisel RD, Rose EA, Gammie JS, DeRose JJ Jr, Puskas JD, Dagenais F, Burks SG, El-Hamamsy I, Milano CA, Atluri P, Voisine P, O'Gara PT, Gelijns AC; CTSN.. Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation. N Engl J Med. 2016 May 19;374(20):1932-41. doi: 10.1056/NEJMoa1602003. PMID: 27040451
  10. Shafiq A, Brawner CA, Aldred HA, Lewis B, Williams CT, Tita C, Schairer JR, Ehrman JK, Velez M, Selektor Y, Lanfear DE, Keteyian SJ. Prognostic value of cardiopulmonary exercise testing in heart failure with preserved ejection fraction. The Henry Ford HospITal CardioPulmonary EXercise Testing (FIT-CPX) project. Am Heart J. 2016 Apr;174:167-72. doi: 10.1016/j.ahj.2015.12.020. PMID: 26995385
  11. Al-Mallah MH, Qureshi WT, Keteyian SJ, Brawner CA, Alam M, Dardari Z, Nasir K, Blaha MJ. Racial Differences in the Prognostic Value of Cardiorespiratory Fitness (Results from the Henry Ford Exercise Testing Project). Am J Cardiol. 2016 May 1;117(9):1449-54. doi: 10.1016/j.amjcard.2016.02.013. PMID: 26976790
  12. Brawner CA, Abdul-Nour K, Lewis B, Schairer JR, Modi SS, Kerrigan DJ, Ehrman JK, Keteyian SJ. Relationship Between Exercise Workload During Cardiac Rehabilitation and Outcomes in Patients With Coronary Heart Disease. Am J Cardiol. 2016 Apr 15;117(8):1236-41. doi: 10.1016/j.amjcard.2016.01.018. PMID: 26897640
  13. Keteyian SJ, Patel M, Kraus WE, Brawner CA, McConnell TR, Piña IL, Leifer ES, Fleg JL, Blackburn G, Fonarow GC, Chase PJ, Piner L, Vest M, O'Connor CM, Ehrman JK, Walsh MN, Ewald G, Bensimhon D, Russell SD; HF-ACTION Investigators. Variables Measured During Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure.
  14. J Am Coll Cardiol. 2016 Feb 23;67(7):780-9. doi: 10.1016/j.jacc.2015.11.050. Erratum in: J Am Coll Cardiol. 2016 Apr 26;67(16):1979-80. PMID: 26892413
  15. Shaya GE, Al-Mallah MH, Hung RK, Nasir K, Blumenthal RS, Ehrman JK, Keteyian SJ, Brawner CA, Qureshi WT, Blaha MJ. High Exercise Capacity Attenuates the Risk of Early Mortality After a First Myocardial Infarction: The Henry Ford Exercise Testing (FIT) Project. Mayo Clin Proc. 2016 Feb;91(2):129-39. doi: 10.1016/j.mayocp.2015.11.012. PMID: 26848000
  16. Keteyian SJ, Kerrigan DJ. Tugging on a Simpler Test to Evaluate Physical Mobility and Function in Patients With Heart Failure. J Card Fail. 2016 Aug;22(8):651-2. doi: 10.1016/j.cardfail.2016.01.002. PMID: 26777756
  17. Brawner CA, Churilla JR, Keteyian SJ. Prevalence of Physical Activity Is Lower among Individuals with Chronic Disease. Med Sci Sports Exerc. 2016 Jun;48(6):1062-7. doi: 10.1249/MSS.0000000000000861. PMID: 26741117
  18. Blaha MJ, Hung RK, Dardari Z, Feldman DI, Whelton SP, Nasir K, Blumenthal RS, Brawner CA, Ehrman JK, Keteyian SJ, Al-Mallah MH. Age-dependent prognostic value of exercise capacity and derivation of fitness-associated biologic age. Heart. 2016 Mar;102(6):431-7. doi: 10.1136/heartjnl-2015-308537. PMID: 26732181
  19. Banks AZ, Mentz RJ, Stebbins A, Mikus CR, Schulte PJ, Fleg JL, Cooper LS, Leifer ES, Badenhop DT, Keteyian SJ, Piña IL, Kitzman DW, Fiuzat M, Whellan DJ, Kraus WE, O'Connor CM. Response to Exercise Training and Outcomes in Patients With Heart Failure and Diabetes Mellitus: Insights From the HF-ACTION Trial. J Card Fail. 2016 Jul;22(7):485-91. doi: 10.1016/j.cardfail.2015.12.007. PMID: 26687984
  20. Adesiyun T, Zhao D, Blaha MJ, Brawner CA, Keteyian SJ, Ehrman JK, Al-Mallah MH, Michos ED. Exercise Parameters and Risk of Coronary Artery Disease and Mortality Among Patients Who Use Pulmonary Medications: The FIT Project. Am J Med. 2016 Apr;129(4):446.e1-4. doi: 10.1016/j.amjmed.2015.11.013. PMID: 26656760
  21. Kerrigan DJ, Williams CT, Brawner CA, Ehrman JK, Saval MA, Peterson EL, Lanfear DE, Tita C, Velez M, Selektor Y, Keteyian SJ. Heart Rate and V˙O2 Concordance in Continuous-Flow Left Ventricular Assist Devices. Med Sci Sports Exerc. 2016 Mar;48(3):363-7. doi: 10.1249/MSS.0000000000000776. PMID: 26414318
  22. Aladin AI, Al Rifai M, Rasool SH, Keteyian SJ, Brawner CA, Michos ED, Blaha MJ, Al-Mallah MH, McEvoy JW. The Association of Resting Heart Rate and Incident Hypertension: The Henry Ford Hospital Exercise Testing (FIT) Project. Am J Hypertens. 2016 Feb;29(2):251-7. doi: 10.1093/ajh/hpv095. PMID: 26112864

Phillip D Levy, M.D.
Wayne State University
Department Emergency Medicine

  1. Ayaz SI, Sharkey CM, Kwiatkowski GM, Wilson SS, John RS, Tolomello R, Mahajan A, Millis S, Levy PD. Intravenous enalaprilat for treatment of acute hypertensive heart failure in the emergency department. Int J Emerg Med. 2016 Dec;9(1):28. doi: 10.1186/s12245-016-0125-4. PMID: 28032307 Free PMC Article
  2. Janke AT, McNaughton CD, Brody AM, Welch RD, Levy PD. Trends in the Incidence of Hypertensive Emergencies in US Emergency Departments From 2006 to 2013. J Am Heart Assoc. 2016 Dec 5;5(12). pii: e004511. PMID: 27919932 
  3. Levy PD, Willock RJ, Burla M, Brody A, Mahn J, Marinica A, Nasser SA, Flack JM. Total antihypertensive therapeutic intensity score and its relationship to blood pressure reduction. J Am Soc Hypertens. 2016 Dec;10(12):906-916. doi: 10.1016/j.jash.2016.10.005. PMID: 27856202
  4. Wilson SS, Kwiatkowski GM, Millis SR, Purakal JD, Mahajan AP, Levy PD. Use of nitroglycerin by bolus prevents intensive care unit admission in patients with acute hypertensive heart failure. Am J Emerg Med. 2017 Jan;35(1):126-131. doi: 10.1016/j.ajem.2016.10.038. PMID: 27825693
  5. McNaughton CD, Brody A, Levy PD. Appropriate Management of Asymptomatic Hypertension. JAMA Intern Med. 2016 Nov 1;176(11):1723-1724. doi: 10.1001/jamainternmed.2016.5925. PMID: 27820641
  6. Brody A, Twiner M, Kumar A, Goldberg E, McNaughton C, Souffront K, Millis S, Levy PD. Survey of Emergency Physician Approaches to Management of Asymptomatic Hypertension. J Clin Hypertens (Greenwich). 2016 Sep 28. doi: 10.1111/jch.12921. PMID: 27677856
  7. Brody AM, Sharma VK, Singh A, Kumar VA, Goldberg EM, Millis SR, Levy PD. Barriers to emergency physician diagnosis and treatment of uncontrolled chronic hypertension. Am J Emerg Med. 2016 Nov;34(11):2241-2242. doi: 10.1016/j.ajem.2016.08.050. PMID: 27623082
  8. Goldberg EM, Levy PD, McNaughton CD. When More Isn't Better: Visits for Hypertension: September 2016 Annals of Emergency Medicine Journal Club. Ann Emerg Med. 2016 Sep;68(3):385-6. doi: 10.1016/j.annemergmed.2016.07.002. PMID: 27568422
  9. Barrett TW, Rising KL, Bellolio MF, Hall MK, Brody A, Dodd KW, Grieser M, Levy PD, Raja AS, Self WH, Weingarten G, Hess EP, Hollander JE. The 2016 Academic Emergency Medicine Consensus Conference, "Shared Decision Making in the Emergency Department: Development of a Policy-relevant Patient-centered Research Agenda" Diagnostic Testing Breakout Session Report. Acad Emerg Med. 2016 Dec;23(12):1354-1361. doi: 10.1111/acem.13050. PMID: 27404959
  10. Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DE, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink JR, Butler J. Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society for Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group. Acad Emerg Med. 2016 Aug;23(8):922-31. doi: 10.1111/acem.13025. PMID: 27286136
  11. Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink JR, Butler J. Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society of Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group. J Card Fail. 2016 Aug;22(8):618-27. doi: 10.1016/j.cardfail.2016.04.015. PMID: 27262665
  12. Martindale J, Wakai A, Collins SP, Levy PD, Diercks D, Hiestand BC, Fermann GJ, deSouza I, Sinert R. In Reply. Acad Emerg Med. 2016 Jul;23(7):843. doi: 10.1111/acem.12970. PMID: 27168480
  13. Goldberg EM, Levy PD. New Approaches to Evaluating and Monitoring Blood Pressure. Curr Hypertens Rep. 2016 Jun;18(6):49. doi: 10.1007/s11906-016-0650-9. Review. PMID: 27137524
  14. Miller JB, Kinni H, Amer A, Levy PD. Therapies to Reduce Blood Pressure Acutely. Curr Hypertens Rep. 2016 Jun;18(6):43. doi: 10.1007/s11906-016-0651-8. Review. PMID: 27125389
  15. Martindale JL, Wakai A, Collins SP, Levy PD, Diercks D, Hiestand BC, Fermann GJ, deSouza I, Sinert R. Diagnosing Acute Heart Failure in the Emergency Department: A Systematic Review and Meta-analysis. Acad Emerg Med. 2016 Mar;23(3):223-42. doi: 10.1111/acem.12878. Review. PMID: 26910112
  16. Emergency Department Patients With Chest Pain Writing Panel., Rybicki FJ, Udelson JE, Peacock WF, Goldhaber SZ, Isselbacher EM, Kazerooni E, Kontos MC, Litt H, Woodard PK; Emergency Department Patients With Chest Pain Rating Panel.; Appropriate Utilization of Cardiovascular Imaging Oversight Committee. 2015 ACR/ACC/AHA/AATS/ACEP/ASNC/NASCI/SAEM/SCCT/SCMR/SCPC/ SNMMI/STR/STS Appropriate Utilization of Cardiovascular Imaging in Emergency Department Patients With Chest Pain: A Joint Document of the American College of Radiology Appropriateness Criteria Committee and the American College of Cardiology Appropriate Use Criteria Task Force. J Am Coll Radiol. 2016 Feb;13(2):e1-e29. doi: 10.1016/j.jacr.2015.07.007. PMID: 26810814
  17. Spranger MD, Krishnan AC, Levy PD, O'Leary DS, Smith SA. Reply to "Letter to the editor: Applying the blood flow restriction pressure: the elephant in the room". Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H134-5. doi: 10.1152/ajpheart.00878.2015. PMID: 26724282
  18. Peacock WF, Levy PD, Gonzalez MG, Than M. Target-specific Oral Anticoagulants in the Emergency Department. J Emerg Med. 2016 Feb;50(2):246-57. doi: 10.1016/j.jemermed.2015.02.052. Review. PMID: 26614713
  19. Janke AT, Overbeek DL, Kocher KE, Levy PD. Exploring the Potential of Predictive Analytics and Big Data in Emergency Care. Ann Emerg Med. 2016 Feb;67(2):227-36. doi: 10.1016/j.annemergmed.2015.06.024. PMID: 26215667

Ida Llewellyn-Smith, Ph.D.
Flinders University (Australia)
Department of Medicine
Centre for Neuroscience

  1. Etlin A, Bráz JM, Kuhn JA, Wang X, Hamel KA, Llewellyn-Smith IJ, Basbaum AI. Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord. J Neurosci. 2016 Nov 16;36(46):11634-11645. PMID: 27852772
  2. Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA.  The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. J Physiol. 2016 May 15;594(10):2607-28. doi: 10.1113/JP272322. PMID: 26931093
  3. Verberne AJ, Korim WS, Sabetghadam A, Llewellyn-Smith IJ. Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. Br J Pharmacol. 2016 May;173(9):1425-37. doi: 10.1111/bph.13458. Review. PMID: 26896587
  4. Korim WS, Llewellyn-Smith IJ, Verberne AJ. Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia: Involvement of Orexin Type 2 (OX2-R) Receptors. Endocrinology. 2016 Feb;157(2):810-9. doi: 10.1210/en.2015-1712. PMID: 26653571

Pablo Ortiz, Ph.D.
Henry Ford Hospital
Division of Hypertension and Vascular Research

  1. Ortiz PA. K+-Mediated Regulation of Distal Convoluted Tubule Na/Cl Cotransporter Phosphorylation During Angiotensin II-Induced Hypertension. Hypertension. 2016 Oct;68(4):853-4. doi: 10.1161/HYPERTENSIONAHA.116.07533. PMID: 27600180
  2. Caceres PS, Mendez M, Haque MZ, Ortiz PA. Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE. J Biol Chem. 2016 Oct 14;291(42):22063-22073. PMID: 27551042
  3. Ramseyer VD, Ortiz PA, Carretero OA, Garvin JL. Angiotensin II-mediated hypertension impairs nitric oxide-induced NKCC2 inhibition in thick ascending limbs. Am J Physiol Renal Physiol. 2016 Feb 17:ajprenal.00473.2015. doi: 10.1152/ajprenal.00473.2015. [Epub ahead of print] PMID: 26887831
  4. Jaykumar AB, Caceres PS, Sablaban I, Tannous BA, Ortiz PA. Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy. Am J Physiol Renal Physiol. 2016 Jan 15;310(2):F183-91. doi: 10.1152/ajprenal.00104.2015. PMID: 26538436

Suresh S. Palaniyandi, Ph.D.
Henry Ford Hospital
Division of Hypertension and Vascular Research

  1. Karuppagounder V, Arumugam S, Giridharan VV, Sreedhar R, Bose RJ, Vanama J, Palaniyandi SS, Konishi T, Watanabe K, Thandavarayan RA. Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy. Nutrition. 2017 Feb;34:47-54. doi: 10.1016/j.nut.2016.09.005. Review. PMID: 28063511
  2. Pan G, Deshpande M, Thandavarayan RA, Palaniyandi SS. ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes. J Diabetes Res. 2016;2016:1390861. PMID: 27882330
  3. Karuppagounder V, Arumugam S, Babu SS, Palaniyandi SS, Watanabe K, Cooke JP, Thandavarayan RA. The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging. Ageing Res Rev. 2016 Nov 5. pii: S1568-1637(16)30223-9. doi: 10.1016/j.arr.2016.10.006. Review. PMID: 27825897
  4. Mali VR, Pan G, Deshpande M, Thandavarayan RA, Xu J, Yang XP, Palaniyandi SS. Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity. PLoS One. 2016 Oct 13;11(10):e0163158. doi: 10.1371/journal.pone.0163158. PMID: 27736868
  5. Deshpande M, Mali VR, Pan G, Xu J, Yang XP, Thandavarayan RA, Palaniyandi SS. Increased 4-hydroxy-2-nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion. Cell Biochem Funct. 2016 Jul;34(5):334-42. doi: 10.1002/cbf.3195. PMID: 27273517
  6. Sreedhar R, Giridharan VV, Arumugam S, Karuppagounder V, Palaniyandi SS, Krishnamurthy P, Quevedo J, Watanabe K, Konishi T, Thandavarayan RA. Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice. Biofactors. 2016 Jul 8;42(4):368-75. doi: 10.1002/biof.1280. PMID: 27087487
  7. Karuppagounder V, Giridharan VV, Arumugam S, Sreedhar R, Palaniyandi SS, Krishnamurthy P, Quevedo J, Watanabe K, Konishi T, Thandavarayan RA. Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. PLoS One. 2016 Apr 12;11(4):e0152922. doi: 10.1371/journal.pone.0152922. PMID: 27070323
  8. Munukutla S, Pan G, Deshpande M, Thandavarayan RA, Krishnamurthy P, Palaniyandi SS. Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble? Alcohol Clin Exp Res. 2016 Apr;40(4):686-97. doi: 10.1111/acer.13008. Review. PMID: 27013182
  9. Mali VR, Deshpande M, Pan G, Thandavarayan RA, Palaniyandi SS. Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes. Cell Signal. 2016 Feb;28(2):1-6. doi: 10.1016/j.cellsig.2015.11.006. PMID: 26577527

Nour-Eddine Rhaleb, Ph.D.
Henry Ford Hospital
Division of Hypertension and Vascular Research

  1. González GE, Rhaleb NE, D'Ambrosio MA, Nakagawa P, Liao TD, Peterson EL, Leung P, Dai X, Janic B, Liu YH, Yang XP, Carretero OA. Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1287-H1296. doi: 10.1152/ajpheart.00096.2016. PMID: 27496875
  2. Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JM, Rhaleb NE, Carretero OA. The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase. Am J Physiol Renal Physiol. 2016 May 15;310(10):F1026-34. doi: 10.1152/ajprenal.00562.2015. PMID: 26962108
  3. Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, Carretero OA. Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1176-83. doi: 10.1152/ajpheart.00252.2015. PMID: 26945075 1

Noreen F. Rossi, M.D.
Wayne State University
Department of Internal Medicine
Division of Nephrology

  1. Rossi NF, Pajewski R, Chen H, Littrup PJ, Maliszewska-Scislo M. Hemodynamic and neural responses to renal denervation of the nerve to the clipped kidney by cryoablation in two-kidney, one-clip hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15;310(2):R197-208. doi: 10.1152/ajpregu.00331.2015. PMID: 26582638
  2. Massey KJ, Li Q, Rossi NF, Keezer SM, Mattingly RR, Yingst DR. Phosphorylation of rat kidney Na-K pump at Ser938 is required for rapid angiotensin II-dependent stimulation of activity and trafficking in proximal tubule cells. Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C227-32. doi: 10.1152/ajpcell.00113.2015. PMID: 26582472

Takeshi Sakamoto, Ph.D.
Wayne State University
Department Biophysics and Biomedical Physics

  1. Gunther LK, Feng HZ, Wei H, Raupp J, Jin JP, Sakamoto T. Effect of N-Terminal Extension of Cardiac Troponin I on the Ca(2+) Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils. Biochemistry. 2016 Mar 29;55(12):1887-97. doi: 10.1021/acs.biochem.5b01059. PMID: 26862665

Thomas Sanderson, Ph.D.
Wayne State University
Department of Emergency Medicine

  1. Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE. J Biol Chem. 2017 Jan 6;292(1):64-79. doi: 10.1074/jbc.M116.744664. PMID: 27758862
  2. Kumar R, Bukowski MJ, Wider JM, Reynolds CA, Calo L, Lepore B, Tousignant R, Jones M, Przyklenk K, Sanderson TH. Mitochondrial dynamics following global cerebral ischemia. Mol Cell Neurosci. 2016 Oct;76:68-75. doi: 10.1016/j.mcn.2016.08.010. PMID: 27567688

Robert Sokol, M.D.
Wayne State University
Department of Obstetrics and Gynecology
C.S. Mott center for Human Growth and Development

  1. Maslowsky J, Schulenberg J, Chiodo LM, Hannigan JH, Greenwald MK, Janisse J, Sokol RJ, Delaney-Black V. Parental Support, Mental Health, and Alcohol and Marijuana Use in National and High-Risk African-American Adolescent Samples. Subst Abuse. 2016 Jan 11;9(Suppl 1):11-20. doi: 10.4137/SART.S22441. PMID: 26843811  
  2. Ondersma SJ, Beatty JR, Rosano TG, Strickler RC, Graham AE, Sokol RJ. Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) Testing is Not Vulnerable to Incidental Alcohol Exposure in Pregnant Women. Subst Use Misuse. 2016 Jan 2;51(1):126-30. doi: 10.3109/10826084.2015.1073324. PMID: 26771303  
  3. Vilchez G, Dai J, Gill N, Lagos M, Bahado-Singh R, Sokol RJ. Racial disparities in the optimal for induction of labor in low-risk term pregnancies: a national population-based study. J Matern Fetal Neonatal Med. 2016;29(8):1279-82. doi: 10.3109/14767058.2015.1045865. PMID: 26004983
  4. Sokol RJ. Molecular Chaperones as Therapy for PFIC: Not So Fast! J Pediatr Gastroenterol Nutr. 2016 Jan 14.  PMID: 26771769

Updated: March 14, 2017