Wayne State University

Warrior strong
Login
Search

School of Medicine

Physiology

Holcomb Publications

  1. Munkanatta Godage DNP, VanHecke GC, Samarasinghe KTG, Feng HZ, Hiske M, Holcomb J, Yang Z, Jin JP, Chung CS, Ahn YH. SMYD2 glutathionylation contributes to degradation of sarcomeric proteins. Nat Commun. 2018 Oct 18;9(1):4341. doi: 10.1038/s41467-018-06786-x. PMID: 30337525
  2. Kuiper BD, Keusch BJ, Holcomb J, Muzzarelli KM, Amblard F, Liu P, Zhou S, Kovari IA, Yang Z, Schinazi RF, Kovari LC. Expression, purification, and characterization of a GII.4 norovirus protease. Infect Disord Drug Targets. 2018 May 20. doi: 10.2174/1871526518666180521091158 PMID: 29779487
  3. Holcomb J, Doughan M, Spellmon N, Lewis B, Perry E, Zhang Y, Nico L, Wan J, Chakravarthy S, Shang W, Miao Q, Stemmler T, Yang Z. SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains. PLoS One. 2018 Jan 18;13(1):e0191371. doi: 10.1371/journal.pone.0191371. eCollection 2018. PMID: 29346419 PMCID: PMC5773207
  4. Holcomb J, Spellmon N, Zhang Y, Doughan M, Li C, Yang Z. Protein crystallization: Eluding the bottleneck of X-ray crystallography. AIMS Biophys. 2017;4(4):557-575. doi: 10.3934/biophy.2017.4.557. Epub 2017 Sep 26. PMID: 29051919 PMCID: PMC5645037
  5. Kuiper BD, Slater K, Spellmon N, Holcomb J, Medapureddy P, Muzzarelli KM, Yang Z, Ovadia R, Amblard F, Kovari IA, Schinazi RF, Kovari LC. Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease. Biochem Biophys Res Commun. 2017 Mar 22. pii: S0006-291X(17)30567-3. doi: 10.1016/j.bbrc.2017.03.108. PMID: 28342876
  6. Spellmon N, Holcomb J, Niu A, Choudhary V, Sun X, Zhang Y, Wan J, Doughan M, Hayden S, Hachem F, Brunzelle J, Li C, Yang Z. Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF. Biochem Biophys Res Commun. 2017 Apr 1;485(2):529-534. doi: 10.1016/j.bbrc.2017.02.010. PMID: 28179147
  7. Spellmon N, Sun X, Xue W, Holcomb J, Chakravarthy S, Shang W, Edwards B, Sirinupong N, Li C, Yang Z. New open conformation of SMYD3 implicates conformational selection and allostery. AIMS Biophys. 2017;4(1):1-18. doi: 10.3934/biophy.2017.1.1. PMID: 28050603
  8. Jiang Y, Holcomb J, Spellmon N, Yang Z. Purification of Histone Lysine Methyltransferase SMYD2 and Co-Crystallization with a Target Peptide from Estrogen Receptor α. Methods Mol Biol. 2016;1366:207-17. PMID: 26585137
  9. Hou Y, Wu Y, Farooq SM, Guan X, Wang S, Liu Y, Oblak JJ, Holcomb J, Jiang Y, Strieter RM, Lasley RD, Arbab AS, Sun F, Li C, Yang Z. A critical role of CXCR2 PDZ-mediated interactions in endothelial progenitor cell homing and angiogenesis. Stem Cell Res. 2015 Mar;14(2):133-43. PMID: 25622052
  10. Spellmon N, Holcomb J, Trescott L, Sirinupong N, Yang Z. Structure and function of SET and MYND domain-containing proteins. Int J Mol Sci. 2015 Jan 8;16(1):1406-28. doi: 10.3390/ijms16011406. Review. PMID: 25580534
  11. Holcomb J, Spellmon N, Trescott L, Sun F, Li C, Yang Z. PDZ Structure and Implication in Selective Drug Design against Cystic Fibrosis. Curr Drug Targets. 2015;16(9):945-50. Review. PMID: 25523900
  12. Holcomb J, Jiang Y, Guan X, Trescott L, Lu G, Hou Y, Wang S, Brunzelle J, Sirinupong N, Li C, Yang Z. Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization. Biochem Biophys Res Commun. 2014 May 30;448(2):169-74. PMID: 24768637
  13. Holcomb J, Jiang Y, Lu G, Trescott L, Brunzelle J, Sirinupong N, Li C, Naren AP, Yang Z. Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation. Biochem Biophys Res Commun. 2014 Mar 28;446(1):399-403. PMID: 24613836
  14. JiangY, Holcomb J, Trescott L, Rice M, Yang Z. Structural Dissection of Cardiogenic and Myogenic SMYD Proteins. Experimental and clinical cardiology, Accepted, October 15, (2014).
  15. Trescott L, Holcomb J, Spellmon N, Mcleod C, Aljehane L, Sun F, Li C, Yang Z. Targeting the Root Cause of Cystic Fibrosis. Curr Drug Targets. 2015;16(9):933-44. Review. PMID: 25316272
  16. Jiang Y, Wang S, Holcomb J, Trescott L, Guan X, Hou Y, Brunzelle J, Sirinupong N, Li C, Yang Z. Crystallographic analysis of NHERF1-PLCβ3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer. Biochem Biophys Res Commun. 2014 Apr 4;446(2):638-43. PMID: 24642259
  17. Jiang Y, Trescott L, Holcomb J, Zhang X, Brunzelle J, Sirinupong N, Shi X, Yang Z. Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation. J Mol Biol. 2014 Oct 9;426(20):3413-25. PMID: 24594358
  18. Rice M, Jiang Y, Holcomb J, Trescott L, Spellmon N, Sirinupong N, Yang Z. SMYD2 Structure and Function: A Multispecificity Protein Lysine Methyltransferase. Journal of Cytology and Molecular Biology, 1(2):7, (2014).