Research Focus:
An in vitro cell line model was developed in our laboratory to study the consequences of prolonged dietary agent exposure on tumor cell growth and responses to chemotherapy.
We have recently developed a series of paired cell lines to study the effects of diet on cancer progression and drug treatment responses. The cell lines in this model consist of parent and subline cell pairs that derive from a single genetically identical cell line of origin. The sublines were established by long term exposure to very low doses of dietary agents or pharmaceuticals. The corresponding parent cell lines were initiated and maintained in parallel cultures using unsupplemented, but otherwise identical media.