William Beierwaltes Ph.D.

William Beierwaltes Ph.D.


Henry Ford Hospital, 7121 E & R Building, Grand Blvd., Detroit, MI


William Beierwaltes Ph.D.

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Recently, my research has examined the role of the potent vasodilator nitric oxide as an intrinsic regulator of renin secretion. We have identified and described both inhibitory and stimulatory pathways for the interaction between nitric oxide and renin. Nitric oxide, derived from the endothelium via the endothelial nitric oxide synthase, produced in response to vascular shear stress, has a direct inhibitory action on renin through its second messenger cGMP. Conversely, nitric oxide from the macula densa in the nephron, via the neuronal isoform of nitric oxide synthase, suppresses the degradation of the renin-stimulating second messenger cAMP by inhibiting phosphodiesterase-3 in the juxtaglomerular cells. We continue to examine the pathways by which the secretion of renin is regulated.

We have also studied the interaction between the renin-angiotensin system and nitric oxide in the kidney, and how this balance of intrinsic vasoconstrictor and vasodilator systems regulates renal blood flow, renal perfusion and function. We have also extensively described how this interaction is altered and disrupted in both acute and chronic renovascular hypertension.

To carry out these studies we employ an integrated approach which includes studies using cell culture, special cell isolations, and organ studies which are supported by a number of assay systems and molecular techniques. We also employ an extensive in vitro array of tools employing genetic and experimental models of hypertension as well as mutant knockout murine strains.