Fei Sun M.D., Ph.D.

Fei Sun M.D., Ph.D.

fsun@med.wayne.edu

5229 Scott Hall

313-577-2428

313-577-5494 (fax)

Fei Sun M.D., Ph.D.

Position Title

Assistant Professor

Areas of Interest

The role of Derlin-1 complex in CFTR biogenesis; The role of molecular chaperones in ΔF508CFTR degradation and maturation

Research

Research in my laboratory is focused on understanding the molecular mechanisms of biogenesis and quality control pathways that regulate protein expression and trafficking of cystic fibrosis transmembrane conductance regulator (CFTR), which functions as a cAMP-dependent Cl- channel at the apical membrane of epithelial cells. Mutations in CFTR gene are responsible for cystic fibrosis, a lethal inherited disease. The misfolded cystic fibrosis protein caused by the mutations is prematurely targeted to endoplasmic reticulum associated protein degradation (ERAD), a cellular process in which the misfolded protein is ubiquitinated and subsequently degraded by the proteasome. The importance of understanding ERAD process in CFTR is underscored by the fact that interruption of the early stages of the ERAD process could restore the mutant CFTR trafficking and function. In addition, we are interested in ERAD of other misfolded proteins in the secretory pathway, such as insulin because mutations in this gene cause neonatal diabetes.

Image - Wild-type and ΔF508 CFTR Biogenesis

Publications

 For a list of Dr. Sun's Publications visit PubMed-Sun

Post Graduate Training

  • 1991-1993 Research Assistant, University of Alabama at Birmingham, Birmingham, AL
  • 1988-1989 Medicine Instructor, Department of Preventive Medicine, Nanjing Medical College
  • 1983-1988 Post-graduate, Department of Preventive Medicine, Nanjing Medical College

Education

  • 2000 - PhD in Cell Biology: University of Pittsburgh, Department of Cell Biology and Physiology, Pittsburgh, PA
  • 1990 - MPH in Epidemiology: University of Alabama, Department of Epidemiology and Biostatistics, Birmingham, AL
  • 1983 - MD: Nanjing Medical University, Nanjing, China