Office Address5253 Scott Hall
Position TitleAssociate Professor Emeritus
Areas of InterestCellular and molecular physiology; regulation of membrane transport
Physiological concentrations of angiotensin II (Ang II) (10-12 to 10-9) stimulate sodium reabsorption in the proximal tubule, which in turn affects blood pressure, and contributes to the development of hypertension. Our recent work shows that Ang II rapidly (≤ 2 min), directly, and robustly stimulates the activity of Na,K-ATPase, the active transport mechanism that ultimately drives sodium reabsorption. Under these conditions Ang II also alters the phosphorylation and conformation of Na,K-ATPase. To test the role of phosphorylation in regulating pump activity we have co-expressed the rat α-subunit in opossum kidney cells, a proximal tubule cell line, along with AT1A receptor. In these cells Ang II stimulates the activity of the rat sodium proximal tubule. By doing site-directed mutagenesis we plan to test which sites of phosphorylation are responsible for the observed stimulation.
Dr. Yingst is not accepting new students.
Laboratory Web Site
A list of Dr. Yingst's publications can be found at PubMed-Yingst
Post Graduate Training
- 1976-78 NIH Postdoctoral Fellow at Yale University, Department of Physiology
- 1978-79 Postdoctoral Associate Yale University, Department of Physiology
Awards & Honors
2015 Wayne State University School of Medicine College Teaching Award
- Cellular processes that control sodium reabsorption in the kidneys