Office Address

VA B-4333

Position Title

Professor 

Joint Appointments

Associate Chair for Research (Department of Internal Medicine)                                                                                                  Research Career Scientist Detroit VA Medical Center

Areas of Interest

Neural control of respiratory and cardiovascular responses in humans during sleep
Respiratory plasticity in response to intermittent hypoxia
Cardiac and autonomic responses to intermittent hypoxia

Serotonin, breathing instability and heart failure in spinal cord injury 

 

Research

Dr. Mateika is a Professor in the Department of Physiology at Wayne State University and a VA Research Career Scientist. He is a respiratory physiologist who is presently investigating the impact of genetically or spinal cord injury induced reductions in central nervous system serotonin on mechanisms that influence breathing stability and cardiovascular/autonomic function in mice. Dr. Mateika is also exploring if repeated daily exposure to mild intermittent hypoxia enhances the impact of continuous positive airway pressure on co-morbidities linked to sleep apnea in humans with intact or injured spinal cords. Dr. Mateika's research is presently funded by the National Institutes of Health and Veterans Affairs.

Dr. Mateika is accepting new MS and PhD students for the 2025-2026 academic year. Dr. Mateika is also accepting applications for post-doctoral fellows.

Publications

(2018-2025)

1. Mateika JH. The complex nature of blood pressure control during rest and exercise in humans: The role of the carotid chemoreflex. J Physiol. 603, 2179-2180, 2025.
2. Qiu Q, Komnenov D, Hali M, Chung CS, Mueller PJ, Rossi NF, Kuhn DM, Mateika JH. Systolic and diastolic dysfunction is exacerbated by age and spinal cord injury in male and female mice with central nervous system serotonin deficiency. J Physiol. 603, 1375-1397, 2025.
3. Mateika JH, Barok R, Kissane D. Is sustained hypercapnia required to initiate plasticity in humans exposed to mild intermittent hypoxia? J Physiol. 602, 5125-5128, 2024.
4. Ji W, Nightingale TE, Zhao F, Fritz NE, Phillips AA, Sisto SA, Nash MS, Badr MS, Wecht JM, Mateika JH, Panza GS. The clinical relevance of autonomic dysfunction, cerebral hemodynamics, and sleep interactions in individuals living with SCI. Arch Phys Med Rehabil. 105:166-176, 2024.
5. Panza GS, Kissane DM, Puri S, Mateika JH. The hypoxic ventilatory response and hypoxic burden are predictors of the magnitude of ventilatory long-term facilitation in humans. J Physiol. 601:4611-4623, 2023. Highlighted in following editorial: Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans Ken D. O'Halloran. J Physiol. 601:4477-4478, 2023.
6. Racial differences in upper airway collapsibility and loop gain in young adult males. Puri S, Panza GS, Kissane D, Jones S, Reck K, Lin HS, Badr MS, Mateika JH. Sleep. 46: zsad091, 2023. Highlighted in following editorial: A deep dive into the physiological differences responsible for OSA between races. Edwards BA, O'Driscoll DM, Brooker EJ, Landry SA. Sleep. 46: zsad186, 2023.
7. Pho H, Amorim MR, Qiu Q, Shin M-K, Kim LJ, Anokye-Danso F, Jun JJ, Ahima RS, Branco LGS, Kuhn DM, Mateika JH and Polotsky V. The effect of brain serotonin deficiency on breathing during sleep is magnified by age. Physio Rep. 10: 1-11, 2022.
8. Panza GS, Puri S, Lin HS, Mateika JH. Divergent ventilatory and blood pressure responses are evident following repeated daily exposure to mild intermittent hypoxia in males with OSA and hypertension. Front. Physiol. 13: 897978, 2022.
9. Panza GS, Puri S, Lin HS, Badr MS, Mateika JH. Daily exposure to mild intermittent hypoxia reduces blood pressure in OSA patients with hypertension. Am. J. Respir. and Crit. Care Med. 205: 949-958, 2022. Highlighted in following editorials: Eckert DJ and Sands S. Hypoxia and sleep-disordered breathing: Friend or Foe? Am. J. Respir. and Crit. Care Med. 205: 869-872, 2022 & Chen R, Zhao D, Wu Q, Chen X, Lin J, Wang D, Chen M, Lin J, Zheng Z. Mild Intermittent Hypoxia: A new treatment approach for OSA patients with hypertension. Am. J. Respir. and Crit. Care Med. 206, 122-123, 2022.
10. Qingchao Qiu, Mateika JH. Pathophysiology of obstructive sleep apnea in aging women. Current Sleep Medicine Reports. 7 (4): 1-7, 2021.
11. Puri S, Panza G, Mateika JH. A comprehensive review of respiratory, autonomic and cardiovascular responses to intermittent hypoxia in humans. Exp Neurol. 341:1-24, 2021.
12. Reply to Pun. Panza GS, Puri S, Mateika JH. J Appl Physiol, 129:48, 2020.
13. Puri S, El-Chami M, Shaheen D, Ivers B, Panza G, Badr MS, Lin HS, Mateika JH. Variations in loop gain and arousal threshold during NREM sleep are affected by time of day over a 24 hour period in participants with obstructive sleep apnea. J. Appl. Physiol. 129 (4): 800-809, 2020
14. Ahmed S, Safdar M, Morton C, Soave N, Patel R, Castillo K, Lalande S, Jimenez L, Mateika JH, Wessells R. Effect of virtual reality-simulated exercise on sympathovagal balance. PLoS One. 15(7):1-12, 2020.
15. Mateika JH. A reminder that experimentally induced intermittent hypoxia is an incomplete model of OSA and its outcome measures. J Appl Physiol, 127:1620-1621, 2019.
16. Panza GS, Alex RM, Yokhana SS, Lee DS, Badr MS, Mateika JH. Increased oxidative stress, loop gain and the arousal threshold are clinical predictors of increased apnea severity following exposure to intermittent hypoxia. Nat. Sci. Sleep. 11: 265-279, 2019.
17. Alex R, Panza GS, Hakim H, Badr MS, Edwards BA, Sands SA, Mateika JH. Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnea. J. Physiol. 597: 3697-3711, 2019.
18. Mateika JH, Komnenov D, Pop A, Kuhn DM. Genetic depletion of 5-HT increases central apnea frequency and duration and dampens arousal but does not impact the circadian modulation of these variables. J Appl Physiol. 26:1-10, 2019.
19. Mateika JH., Panza GS, Alex R, Castillo K. Pushing and pulling with no end in sight! The role of cross-talk between different forms of respiratory plasticity in modifying sleep apnoea. J Physiol. 597: 3789 - 3790, 2019.
20. Alex R, Panza G, Mateika JH. The role of loop gain in predicting upper airway surgical outcomes-what do we know?  J Thorac Dis. 10:126-129, 2018. 

For a complete list of Dr. Mateika's publications, please click here: PubMed or ResearchGate

Post Graduate Training

Post-Doctoral Fellow, Department of Physiology, University of Arizona, Tucson, AZ

Education

Courses taught by Jason Mateika, Ph.D.

Winter Term 2024

• PSL7400 - Sleep and Breathing in Health and Disease

← Return to listing