Wayne State University

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School of Medicine

Physiology

Jason H. Mateika, Ph.D.

Jason H. Mateika, Ph.D.

jmateika@med.wayne.edu

Jason H. Mateika, Ph.D.

Office Address

VA B-4333

Position Title

Professor

Joint Appointments

Associate Chair for Research (Department of Internal Medicine)                                                                                                  Research Career Scientist Detroit VA Medical Center

Areas of Interest

Neural control of respiration in humans
Respiratory plasticity in response to intermittent hypoxia
Cardiac and autonomic responses to intermittent hypoxia

Research

Dr. Mateika is a Professor in the Department of Physiology at Wayne State University and a VA Research Career Scientist. He is a respiratory physiologist who is presently investigating the impact of genetically or spinal cord injury induced reductions in central nervous system serotonin on mechanisms that influence breathing stability and cardiovascular/autonomic function in mice. Dr. Mateika is also exploring if repeated daily exposure to mild intermittent hypoxia enhances the impact of continuous positive airway pressure on co-morbidities linked to sleep apnea in humans with intact or injured spinal cords. Dr. Mateika's research is presently funded by the National Institutes of Health and Veterans Affairs.

Dr. Mateika is accepting new MS and PhD students for the 2019-2020 academic year. Dr. Mateika is also accepting applications for post-doctoral fellows.

Publications

(2013-2019)

  1. Mateika JH, Komnenov D, Pop A, Kuhn DM. Genetic depletion of 5-HT increases central apnea frequency and duration and dampens arousal but does not impact the circadian modulation of these variables.  J Appl Physiol. 26:1-10, 2019.
  2. Alex R, Panza G, Mateika JH. The role of loop gain in predicting upper airway surgical outcomes-what do we know?  J Thorac Dis. 10:126-129, 2018. 
  3. Mateika JH, Panza G, Alex R, El-Chami M. The impact of intermittent or sustained carbon dioxide on intermittent hypoxia initiated respiratory plasticity. What is the effect of these combined stimuli on apnea severity? Respir Physiol Neurobiol. 256:58-66, 2018.
  4. Lozo T, Komnenov D, Badr MS, Mateika JH. Sex differences in sleep disordered breathing in adults. Respir Physiol Neurobiol. 245:65-75, 2017.
  5. Wains SA, El-Chami M, Lin HS, Mateika JH. Impact of arousal threshold and respiratory effort on the duration of breathing events across sleep stage and time of night.  Respir Physiol Neurobiol. 237:35-41, 2017.
  6. Mateika JH, Komnenov D. Intermittent hypoxia initiated plasticity in humans: A multipronged therapeutic approach to treat sleep apnea and overlapping co-morbidities Exp Neurol. 287:113-129, 2017.
  7. Komnenov D, Solarewicz JZ, Afzal F, Nantwi KD, Kuhn DM, Mateika JH. Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system. J Appl Physiol 121: 545-57, 2016.
  8. El-Chami M, Shaheen D, Ivers B, Syed Z, Badr MS, Lin HS, Mateika JH. Time of day affects the frequency and duration of breathing events and the critical closing pressure during NREM sleep in participants with sleep apnea. J. Appl. Physiol. 119, 617-626, 2015.
  9. Mateika JH.  El-Chami M., Shaheen D. and Ivers B. Intermittent hypoxia: A low risk research tool with therapeutic value in humans. J. Appl. Physiol. 118:520-532, 2015.
  10. Solarewicz, J.Z., Angoa-Perez, M. D.M. Kuhn, Mateika, J.H. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin. Am. J Physiol. Regul. Integr. Comp. Physiol. 308:R10-R17, 2015.
  11. El-Chami M, Shaheen D, Ivers B, Syed Z, Badr MS, Lin HS, Mateika JH. Time of day affects chemoreflex sensitivity and the carbon dioxide reserve during NREM sleep in participants with sleep apnea. J. Appl. Physiol.117:1149-56, 2014.
  12. Tester, N.J., Fuller, D.D., Fromm, J.S., Spiess, M.R., Behrman, A.L. and Mateika, J.H.  Long-term facilitation of ventilation in humans with chronic spinal cord injury.  Am. J. Respir. and Crit. Care Med. 189: 57-65, 2014.
  13. Hickner, S. Hussain, N. Angoa-Perez, M. Francescutti, D.M. Kuhn, D.M., Mateika, J.H. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. J. Appl. Physiol. 116:240-250, 2014.
  14. Duffin J., Mateika, J.H. Cross-talk opposing view: Peripheral and central chemoreflexes have additive effects on ventilation in humans. J. Physiol. 591: 4351-4353, 2013.
  15. Duffin J., Mateika, J.H. Cross-talk opposing view: Peripheral and central chemoreflexes have additive effects on ventilation in humans (Rebuttal). J. Physiol. 591:4363, 2013.
  16. Duffin J., Kubin L., Mateika, J.H. Sleep and breathing. Foreword.  Respir. Physiol. and Neurobiol. 188: 231-232, 2013.
  17. Mateika, J.H., Syed, Z. Intermittent hypoxia, respiratory plasticity and sleep apnea in humans; present knowledge and future investigations. Respir. Physiol. and Neurobiol. 188: 289-300, 2013.
  18. Syed, S. Lin, H.S. and Mateika, J.H. The impact of arousal state, sex and sleep apnea on the magnitude of progressive augmentation and ventilatory long-term facilitation. J Appl Physiol. 114. 52-65, 2013.

For a complete list of Dr. Mateika's publications, please click here: PubMed or ResearchGate

Post Graduate Training

Post-Doctoral Fellow, Department of Physiology, University of Arizona, Tucson, AZ

Awards & Honors

Awards

  • Veterans Affairs Research Career Scientist Award - 2015-2020
  • Oustanding Contribution in Reviewing - Respiratory Physiology and Neurobiology - 2017
  • Star Reviewer - Top 3 reviewer for Journal of Applied Physiology - 2011 & 2014
  • Veterans Affairs Research Career Scientist Award - 2010-2015
  • Teaching Excellence Award - WSU School of Medicine - 2009 & 2016
  • Research Excellence Award - WSU School of Medicine - 2005
  • American Physiological Society - Research Enhancement Award 1999
  • American Thoracic Society Travel Award 1996
  • American Heart Association Post-Doctoral Fellowship 1995-1996
  • Governor General award for academic excellence - Honourable Mention 1994
  • Ontario Graduate Scholarship 1990-1992
  • Medical Research Council of Canada Studentship 1992-1993
  • University of Toronto Doctoral Fellowship 1989-1990
  • University of Toronto Master's Fellowship  1988-89

Honors

  • Journal of Applied Physiology Editorial Board
  • Respiratory Physiology and Neurobiology Editorial Board
  • Executive Board of the American Sleep Medicine Foundation
  • Chair of the American Academy of Sleep Medicine
  • Respiratory, Neurobiology and Sleep Assembly Program Committee - ATS
  • American Academy of Sleep Medicine Research Committee

 

Education

Baccalaureate:
B.Sc., Department of Human Kinetics, University of Guelph, Guelph, Ontario
Graduate:
M.Sc., Department of Physiology, University of Toronto, Toronto, Ontario
Ph.D., Department of Physiology, University of Toronto, Toronto, Ontario

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