Jason Mateika, Ph.D.

Jason Mateika, Ph.D.

Jason Mateika, Ph.D.

Office Address

VA B-4333

Position Title

Professor & Graduate Officer

Joint Appointments

Associate Chair for Research (Department of Internal Medicine)                                                                                                  Research Career Scientist Detroit VA Medical Center

Areas of Interest

Neural control of respiration in humans
Respiratory plasticity in response to intermittent hypoxia
Cardiac and autonomic responses to intermittent hypoxia


Dr. Mateika is a Professor in the Department of Physiology at Wayne State University and a VA Research Career Scientist. He is a respiratory physiologist who is presently investigating the impact of genetically or spinal cord injury induced reductions in central nervous system serotonin on mechanisms that influence breathing stability and cardiovascular/autonomic function in mice. Dr. Mateika is also exploring if repeated daily exposure to mild intermittent hypoxia enhances the impact of continuous positive airway pressure on co-morbidities linked to sleep apnea in humans with intact or injured spinal cords. Dr. Mateika's research is presently funded by the National Institutes of Health and Veterans Affairs.

Dr. Mateika is accepting new MS and PhD students for the 2024-2025 academic year. Dr. Mateika is also accepting applications for post-doctoral fellows.



  1. Puri S, Panza G, Mateika JH. A comprehensive review of respiratory, autonomic and cardiovascular responses to intermittent hypoxia in humans. Exp Neurol. 341:1-24, 2021.
  2. Reply to Pun. Panza GS, Puri S, Mateika JH. J Appl Physiol, 129:48, 2020.
  3. Puri S, El-Chami M, Shaheen D, Ivers B, Panza G, Badr MS, Lin HS, Mateika JH. Variations in loop gain and arousal threshold during NREM sleep are affected by time of day over a 24 hour period in participants with obstructive sleep apnea. J. Appl. Physiol. 129 (4): 800-809, 2020
  4. Ahmed S, Safdar M, Morton C, Soave N, Patel R, Castillo K, Lalande S, Jimenez L, Mateika JH, Wessells R. Effect of virtual reality-simulated exercise on sympathovagal balance. PLoS One. 15(7):1-12, 2020.
  5. Mateika JH. A reminder that experimentally induced intermittent hypoxia is an incomplete model of OSA and its outcome measures. J Appl Physiol, 127:1620-1621, 2019.
  6. Panza GS, Alex RM, Yokhana SS, Lee DS, Badr MS, Mateika JH. Increased oxidative stress, loop gain and the arousal threshold are clinical predictors of increased apnea severity following exposure to intermittent hypoxia. Nat. Sci. Sleep. 11: 265-279, 2019.
  7. Alex R, Panza GS, Hakim H, Badr MS, Edwards BA, Sands SA, Mateika JH. Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnea. J. Physiol. 597: 3697-3711, 2019.
  8. Mateika JH, Komnenov D, Pop A, Kuhn DM. Genetic depletion of 5-HT increases central apnea frequency and duration and dampens arousal but does not impact the circadian modulation of these variables. J Appl Physiol. 26:1-10, 2019.
  9. Mateika JH., Panza GS, Alex R, Castillo K. Pushing and pulling with no end in sight! The role of cross-talk between different forms of respiratory plasticity in modifying sleep apnoea. J Physiol. 597: 3789 - 3790, 2019.
  10. Alex R, Panza G, Mateika JH. The role of loop gain in predicting upper airway surgical outcomes-what do we know?  J Thorac Dis. 10:126-129, 2018. 
  11. El-Chami M, Sudan S, Lin HS, Mateika JH. Exposure to intermittent hypoxia and sustained hypercapnia reduces therapeutic CPAP in participants with obstructive sleep apnea. J. Appl. Physiol., 123:993-1002, 2017.
  12. Mateika JH, Panza G, Alex R, El-Chami M. The impact of intermittent or sustained carbon dioxide on intermittent hypoxia initiated respiratory plasticity. What is the effect of these combined stimuli on apnea severity? Respir Physiol Neurobiol. 256:58-66, 2018.
  13. Lozo T, Komnenov D, Badr MS, Mateika JH. Sex differences in sleep disordered breathing in adults. Respir Physiol Neurobiol. 245:65-75, 2017.
  14. Wains SA, El-Chami M, Lin HS, Mateika JH. Impact of arousal threshold and respiratory effort on the duration of breathing events across sleep stage and time of night.  Respir Physiol Neurobiol. 237:35-41, 2017.
  15. Mateika JH, Komnenov D. Intermittent hypoxia initiated plasticity in humans: A multipronged therapeutic approach to treat sleep apnea and overlapping co-morbidities Exp Neurol. 287:113-129, 2017.
  16. Komnenov D, Solarewicz JZ, Afzal F, Nantwi KD, Kuhn DM, Mateika JH. Intermittent hypoxia promotes recovery of respiratory motor function in spinal cord-injured mice depleted of serotonin in the central nervous system. J Appl Physiol 121: 545-57, 2016.
  17. El-Chami M, Shaheen D, Ivers B, Syed Z, Badr MS, Lin HS, Mateika JH. Time of day affects the frequency and duration of breathing events and the critical closing pressure during NREM sleep in participants with sleep apnea. J. Appl. Physiol. 119, 617-626, 2015.
  18. Mateika JH.  El-Chami M., Shaheen D. and Ivers B. Intermittent hypoxia: A low risk research tool with therapeutic value in humans. J. Appl. Physiol. 118:520-532, 2015.
  19. Solarewicz, J.Z., Angoa-Perez, M. D.M. Kuhn, Mateika, J.H. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin. Am. J Physiol. Regul. Integr. Comp. Physiol. 308:R10-R17, 2015.
  20. El-Chami M, Shaheen D, Ivers B, Syed Z, Badr MS, Lin HS, Mateika JH. Time of day affects chemoreflex sensitivity and the carbon dioxide reserve during NREM sleep in participants with sleep apnea. J. Appl. Physiol.117:1149-56, 2014.
  21. Tester, N.J., Fuller, D.D., Fromm, J.S., Spiess, M.R., Behrman, A.L. and Mateika, J.H.  Long-term facilitation of ventilation in humans with chronic spinal cord injury.  Am. J. Respir. and Crit. Care Med. 189: 57-65, 2014.
  22. Hickner, S. Hussain, N. Angoa-Perez, M. Francescutti, D.M. Kuhn, D.M., Mateika, J.H. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. J. Appl. Physiol. 116:240-250, 2014.

For a complete list of Dr. Mateika's publications, please click here: PubMed or ResearchGate

Post Graduate Training

Post-Doctoral Fellow, Department of Physiology, University of Arizona, Tucson, AZ


B.Sc., Department of Human Kinetics, University of Guelph, Guelph, Ontario
M.Sc., Department of Physiology, University of Toronto, Toronto, Ontario
Ph.D., Department of Physiology, University of Toronto, Toronto, Ontario

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