Mariana Angoa-Perez
Office address
4646 John R
Narrative bio
I have a broad background in neuroscience, with specific training on animal behavior, histopathology, molecular neurochemistry and bioinformatics. I received my PhD in Neurobiology at UNAM where my dissertation studies were directed at the neurotoxic effects of chronic ozone exposure on the dopamine neuronal system. Later, as a postdoctoral associate of Dr. Donald Kuhn, I gained additional experience in the study of the role of serotonin in several neurophysiological processes and neuropathology through the use of a transgenic mouse model lacking this neurotransmitter in the brain. In addition, I have examined the neurotoxicity induced by nerve agents, substituted amphetamines and other agents to the dopamine and serotonin neuronal systems. I later contributed substantially to the development of a highly relevant mouse model of repetitive mild traumatic brain injury. In the course of my research, I have obtained considerable expertise in animal behavior with emphasis in anxiety, depression, and psychostimulant-related assessments. Since 2017, our research has taken an interesting shift to studies that aim to increase our understanding the influence of the gut microbiome in neuropathology and disease. For this, my skillset has expanded to perform 16S rRNA sequencing analyses, data curation and bioinformatics analyses.
Publications
Last 5 years:
- Tobi M, Chaudhari D, Ryan EP, Rossi NF, Koka O, Baxter B, Tipton M, Dutt TS, Tobi Y, McVicker B, Angoa-Perez M. Immune Signatures in Post-Acute Sequelae of COVID-19 (PASC) and Myalgia/Chronic Fatigue Syndrome (ME/CFS): Insights from the Fecal Microbiome and Serum Cytokine Profiles. Biomolecules. 2025 Jun 25;15(7):928. doi: 10.3390/biom15070928. PMID: 40723800
- Winters AD, Francescutti DM, Kracht DJ, Chaudhari DS, Zagorac B, Angoa-Perez M. The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models. Microorganisms. 2025 Jan 3;13(1):77. doi: 10.3390/microorganisms13010077. PMID: 39858845
- Babakr AA, Angoa-Perez M, Chung CS. Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome. Am J Physiol Heart Circ Physiol. 2025 Jan 1;328(1):H159-H160. doi: 10.1152/ajpheart.00812.2024. PMID: 39656508
- Chaudhari DS, Francescutti DM, Winters AD, Koka O, Kracht DJ, Greenberg JM, Theis KR, Angoa-Perez M. Contributions of the gut microbiota to Gulf War Illness susceptibility: Findings from a mouse model. Life Sci. 2024 Dec 15;359:123244. doi: 10.1016/j.lfs.2024.123244. PMID: 39551360
- Greenberg JM, Winters AD, Zagorac B, Kracht DJ, Francescutti DM, Cannella N, Ciccocioppo R, Woods LCS, Mackle J, Hardiman GT, Kuhn BN, Kalivas PW, Kuhn DM, Angoa-Perez M. Long access heroin self-administration significantly alters gut microbiome composition and structure. Front Psychiatry. 2024 Feb 27;15:1369783. doi: 10.3389/fpsyt.2024.1369783. eCollection 2024. PMID: 38476614
Angoa-Perez M, Kuhn DM. The pharmacology and neurotoxicology of synthetic cathinones. Adv Pharmacol. 2024;99:61-82. doi: 10.1016/bs.apha.2023.12.001. PMID: 38467489 - Angoa-Pérez M, Zagorac B, Francescutti DM, Shaffer ZD, Theis KR, Kuhn DM. Cocaine hydrochloride, cocaine methiodide and methylenedioxypyrovalerone (MDPV) cause distinct alterations in the structure and composition of the gut microbiota. Sci Rep. 2023 Aug 23;13(1):13754. doi: 10.1038/s41598-023-40892-1. PMID: 37612353
- Angoa-Pérez M, Zagorac B, Francescutti DM, Theis KR, Kuhn DM. Effects of gut microbiota remodeling on the dysbiosis induced by high fat diet in a mouse model of Gulf war illness. Life Sci. 2021 Aug 15;279:119675. doi: 10.1016/j.lfs.2021.119675. PMID: 34081987
- Angoa-Pérez M, Kuhn DM. Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight. Pharmacol Rev. 2021 Apr;73(2):571-596. doi: 10.1124/pharmrev.120.000144. PMID: 33597276 Free PMC article. Review.
- Angoa-Pérez M, Zagorac B, Francescutti DM, Theis KR, Kuhn DM. Responses to chronic corticosterone on brain glucocorticoid receptors, adrenal gland, and gut microbiota in mice lacking neuronal serotonin. Brain Res. 2021 Jan 15;1751:147190. doi: 10.1016/j.brainres.2020.147190. PMID: 33152342
A complete list of Dr. Angoa-Perez's publications can be found at: https://pubmed.ncbi.nlm.nih.gov/?term=Mariana+Angoa-P%C3%A9rez&sort=date&size=50
Post graduate training
2008-2011 Post Doctoral Fellow in Psychiatry and Behavioural Neurosciences at Wayne State University
2004-2005 Visting Reseach Fellow at Henry Ford Health System, WIlliam T Gossett Neurology Laboratories
Education
2007 Ph.D. in Biomedical Sciences, Nation Autonomous University of Mexico
2003 B.S. in Biology, Autonomous University of Puebla Mexico