Paulo Caceres Puzzella, Ph.D.

Paulo Caceres Puzzella, Ph.D.


Paulo Caceres Puzzella, Ph.D.

Office Address

6135 Woodward Ave
1414 iBIO

Position Title

Assistant Scientist-Hypertension and Vascular Research Division, Henry Ford Hospital
Assistant Professor (FTA)-Department of Physiology, Wayne State University

Areas of Interest

Epithelial polarity, Kidney physiology, Angiogenesis, Diabetes, Hypertension


Our research aims to identify cell-cell communication mechanisms between epithelial and endothelial cells, and to determine how they contribute to tissue homeostasis and disease. The close relationship between epithelial cells and the underlying microvasculature greatly determines the properties of the tissues and organs where they are located. For this reason, our perspective is that these cell types need to be studied as a functional unit. We believe that bidirectional mechanisms of cell-cell communication between epithelial and endothelial cells maintain tissue homeostasis and contribute to the diversity of epithelia (there are over 150 in the body and possibly an equivalent diversity of microvascular phenotypes). We are interested in identifying novel pathways of cell-cell communication that influence polarized epithelial processes and microvascular angiogenesis, with the ultimate goal of establishing them as contributors to diabetic kidney disease and renal control of blood pressure.

Dr. Caceres will consider new MS and PhD studrnt for the 2024-25 academic year.  



  1. Caceres PS, Savickas G, Murray S, Umanath K, Uduman J, Yee J, Liao TD, Bolin S, Levin A, Khan M, Sarkar S, Fitzgerald J, Maskey D, Ormsby A, Sharma Y, Ortiz P. High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19 Outcome. J Am Soc Nephrol. 2021 Jun 4; doi: 10.1681/ASN.2021010059. [Epub ahead of print] PubMed PMID: 34088853.
  2. Caceres PS, Rodriguez-Boulan E. Retinal pigment epithelium polarity in health and blinding diseases. Curr Opin Cell Biol. 2020 Feb;62:37-45. doi: 10.1016/ PubMed PMID: 31518914.
  3. Caceres PS, Ortiz PA. Molecular regulation of NKCC2 in blood pressure control and hypertension. Curr Opin Nephrol Hypertens. 2019 Sep;28(5):474-480. doi: 10.1097/MNH.0000000000000531. PubMed PMID: 31313674.
  4. Gravotta D, Perez Bay A, Jonker CTH, Zager PJ, Benedicto I, Schreiner R, Caceres PS, Rodriguez-Boulan E. Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes. Mol Biol Cell. 2019 Jul 1;30(14):1716-1728. doi: 10.1091/mbc.E18-12-0811. PubMed PMID: 31091172.
  5. Caceres PS, Gravotta D, Zager PJ, Dephoure N, Rodriguez-Boulan E. Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11796-11805. doi: 10.1073/pnas.1821076116. PubMed PMID: 31142645.

A complete list of Dr. Caceres' publications can be found at:

Post Graduate Training

  1. Research Instructor: 2020-2021 Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI.
  2. Postdoctoral Associate: 2016-2020. Ophthalmology Department, Dyson Vision Research Institute, Weill Cornell Medical College, New York, NY.
  3. Postdoctoral Fellow: 2014-2016. Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI.


PhD 2014 - Wayne State University, Department of Physiology

MS 2005 - University of Cordoba, Argentina

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