2799 West Grand Blvd.
Position TitleAssistant Professor
Areas of InterestHypertension, blood pressure, vascular research
I am accepting new MS and PhD students for the 2012-2020 academic year.
Reactive aldehydes and aldehyde dehydrogeanse (ALDH) in dibetes-induced cardiac damage
Hyperglycemia leads to the production of reactive oxygen species (ROS), advanced glycation end-products (AGE) and other aldehydic products such as 4-hydroxy-2-nonenal (4HNE). These toxic products form protein adducts leading to cell damage and organ dysfunction, which may lead to death. In some cases, the link between diabetes-induced cardiovascular, neurological and renal complications and these toxic products has been shown (e.g., methyl glyoxal, an aldehydic precursor of AGE. Aldehyde dehydrogenase (ALDH) is a family of homo-tetrameric enzymes. Mitochondrial ALDH2 detoxifies aldehydes that accumulate under oxidative stress. ALDH2 is particularly important enzyme as it can not only able to protect the mitochondria from this damage, but can also diminish oxidative stress in damaged mitochondria. In our lab, we are planning to determine whether diabetic complications, in particular cardiac damage by hyperglycemia can be reduced by accelerating the removal of these aldehydes by using a novel ALDH activator.
Mast cells and PKC isozymes in cardiac remodeling of diabetic cardiomyopathy
My earlier studies identified that mast cells play an important role in pathological cardiac remodeling and that inhibition of mast cell degranulation can ameliorate HF by preventing the progression of cardiac remodeling. Further studies revealed that inhibition of PKC epsilon (Palaniyandi et al 2008) and beta II (Palaniyandi SS et al. 2011) by selective peptide inhibitors of these isozymes (developed by Mochly-Rosen lab) attenuate mast cell degranulation and thereby result in the attenuation of pathological cardiac remodeling and improvement of HF after hypertension and myocardial infarction (MI), respectively. Based on these observations, we plan to determine whether modulation of PKC isozymes (in particular, PKC beta II) result in the attenuation of cardiac remodeling of diabetic cardiomyopathy.
ALDH in cardiac regeneration
Another new idea is in development stage in the lab that ALDH activity being a marker for stemness in stem cells; we want to understand the role ALDH isozymes in the contribution of repair and regeneration of cardiac tissue after insults.
For view a selected list of Dr. Palaniyandi's publication please visit PubMed
Post Graduate Training
Stanford University School of Medicine, Department of Chemical and Systems Biology (2006-2011)
Awards & Honors
- Ph.D. in Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Science (2006)
- M. Pharm. in Pharmacology, Punjabi University (2002)
- B. Pharm. in Pharmacy, The Tamilnadu Dr. MGR Medical University