Joseph Mannozzi, Ph.D.

Joseph Mannozzi, Ph.D.

Joseph Mannozzi, Ph.D.

Office Address

Elliman Bldg.

Position Title

Assistant Professor of Research

Areas of Interest

Relief of muscle metaboreflex vasoconstriction in heart failure by chronic ablation of skeletal muscle afferents

Narrative Bio

PhD Candidate takes cardiovascular research personally


  1. Mannozzi J, Al-Hassan MH, Kaur J, Lessanework B, Alvarez A, Massoud L, Bhatti T, O'Leary DS. Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise. Front Physiol. 2022 Apr 5;13:835951. doi: 10.3389/fphys.2022.835951. PMID: 35450162 Free PMC article.
  2. Mannozzi J, Kim JK, Sala-Mercado JA, Al-Hassan MH, Lessanework B, Alvarez A, Massoud L, Bhatti T, Aoun K, O'Leary DS. Arterial Baroreflex Inhibits Muscle Metaboreflex Induced Increases in Effective Arterial Elastance: Implications for Ventricular-Vascular Coupling. Front Physiol. 2022 Mar 25;13:841076. doi: 10.3389/fphys.2022.841076. PMID: 35399256 Free PMC article.
  3. Mannozzi J, Al-Hassan MH, Lessanework B, Alvarez A, Senador D, O'Leary DS. Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex. Am J Physiol Regul Integr Comp Physiol. 2021 Sep 1;321(3):R385-R395. doi: 10.1152/ajpregu.00129.2021. PMID: 34259041
  4. Mannozzi J, Massoud L, Kaur J, Coutsos M, O'Leary DS. Ventricular contraction and relaxation rates during muscle metaboreflex activation in heart failure: are they coupled? Exp Physiol. 2021 Feb;106(2):401-411. doi: 10.1113/EP089053. PMID: 33226720 Free PMC article.
  5. Mannozzi J, Kaur J, Spranger MD, Al-Hassan MH, Lessanework B, Alvarez A, Chung CS, O'Leary DS. Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure. Am J Physiol Regul Integr Comp Physiol. 2020 Jul 1;319(1):R1-R10. doi: 10.1152/ajpregu.00040.2020. PMID: 32348680 Free PMC article.
  6. Dombrowski M, Mannozzi J, O'Leary DS. Neural Control of Cardiovascular Function During Exercise in Hypertension. Front Physiol. 2018 Dec 20;9:1829. doi: 10.3389/fphys.2018.01829. eCollection 2018. PMID: 30618837
  7. Mannozzi JT, Filbert VJ, Mackay WJ, Fulford DE, Steele CW. Evaluation of radiant catalytic ionization in reducing Escherichia coli, Listeria innocua and Salmonella typhimurium on representative food contact surfaces. The Texas Journal of Science, 70(1); 2018.


Ph.D. - Wayne State University

B.S. - Edinboro University


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