Office Address

iBIO
6135 Woodward Avenue, Detroit, MI 48202

Position Title

 Associate Professor

Areas of Interest

• Role of inflammation and wound healing in controlling performance and function of implantable devices and biomaterials in vitro and in vivo
• Biomarkes for clinical management of diabetic foot ulcers
• Disparities and diabetes technology
• Role of environmental pollutants and diabetes

Narrative Bio

 Dr. Klueh is a member of the Integrative Biosciences Center and the Center for Urban Responses to Environmental Stressors at Wayne State University. She has been conducting research on diabetes mellitus for the past 20 years. Her research is focused on the impact of inflammation and wound healing pertaining to biofouling of implantable devices. Her laboratory is also engaged in investigating environmental factors and their link to insulin resistance with her collaborators. Specifically, Dr. Klueh’s work has focused on using tissue engineering approaches to investigate issues of biocompatibility and underlying tissue impairment because of implantable devices. Her foundational work has resulted in numerous publications and patents as well as in the creation of Cell and Molecular Tissue Engineering, LLC, a spin-off company designed to translate her work from the bench to the bedside. Her studies are currently funded through NIDDK and NIEHS.

HONORS/AWARDS

Core Awards

• Fellowship for the Design of an Online Course for the Irvin D. Reid Honors College, Wayne State University (2019)
• Junior Faculty Award, American Diabetes Association (2008)
• Society for Biomaterials 2003 Student Award for Outstanding Research in the Doctoral Degree Category, Society for Biomaterials Meeting in Reno, NV (2003)
• Excellence in Teaching Award from Farmington High School (2002)
• Society of Biomaterials 2001 Student Award for Outstanding Research in the Master’s Science Degree Category, Society for Biomaterials Meeting in Minneapolis, MN (2001)
• American Vacuum Society Dorothy and Earl S. Hoffman Travel Scholarship, AVS 47th Internatl. Symposium in Boston, MA (2000)

Mentee Development Award

• Summer 2021 Dissertation Award from Wayne State University Graduate School, Ms. Shereen Kesserwan, M.S., WSU, College of Engineering, Detroit, MI (2021)
• Biomedical Engineering Society Student Design and Research Award (Annual Meeting of Biomedical Engineering Society, Philadelphia, Pennsylvania), Mr. Adam Mulka, B.S., WSU, College of Engineering, Detroit, MI (2019)
• Biomedical Engineering Society Career Development Award (Annual Meeting of Biomedical Engineering Society, Atlanta, GA), Ms. Chafica Kesserwan, M.S., WSU, College of Engineering, Detroit, MI (2018)
• Society of Woman Engineers (SWE) (Finalist for the 2018 Collegiate Research Competition, WE18 Annual Conference Minneapolis, MN), Ms. Chafica Kesserwan, M.S., WSU, College of Engineering, Detroit, MI (2018)
• Medical Student Summer Research Fellowship, Mr. Farhan Chaudhry, WSU, Medical School, Detroit, MI (2018)

TEACHING

• BME 5320 Fundamentals in Implant Technology: Principles and Limitations (Fall 2017, 2018, 2019, 2020, 2021, 2022)
• BME 5995 Special Topics: Current Topics in Diabetes Technology (Winter 2018, 2019, 2021)
• BME 5010 Quantitative Physiology (Winter 2021, Fall 2021, Winter 2022, Fall 2022)
• BME 5995 Hybrid Course for the Irvin D. Reid Honors College (Winter 2020, 2021)
• Bio 4993 Undergraduate Research in Biological Sciences (Fall 2022) – served as mentor to undergraduate students
• MD2 6542 Research Elective 2B Year 2 Medical School (Fall 2022) – served as mentor to medical student
• BME 5998 Honor Thesis – served as mentor to undergraduate students (Fall 2018, Winter 2023)
• BMS 7999 Essays in Basic Medical Science – served as essay committee member (Fall 2017, 2019, 2022, Winter 2023)

 PATENTS

• Uses of Artificial Tissues Containing Genetically Engineered Cells and Cell Support Systems to Enhance the Function of Implanted Materials and Devices (Co-Inventors: Klueh U, Dorsky DI, Kreutzer DL); Publication No.: 8,916,184 (Publication Date: December 23, 2014).
• Artificial Tissue Systems and Uses Thereof (Co-Inventors: Klueh U, Dorsky DI, Kreutzer, DL); Publication No.: 9,247,910 (Publication Date: February 2, 2016).
• Sensors, Cannulas, Collars and Coated Surgical Mesh, and Corresponding Systems and Methods (Co-Inventors: Klueh U, Kreutzer DL); Publication No.: 9,717,583 (Publication Date: August 1, 2017).
• Coated Sensors, and Corresponding Systems and Methods (Co-inventors: Klueh U, Kreutzer DL); Publication No.: 10,130,288 (Publication Date: November 20, 2018).
• Coated Surgical Mesh, and Corresponding Systems and Methods (Co-inventors: Klueh U, Kreutzer DL); Publica-tion No.: 10,405,961 (Publication Date: Sep 10, 2019).
• Systems, Methods and Products for Minimizing Tissue Reactions and Tissue Injury at an Infusion Site (Co-inventors: Klueh U, Kreutzer DL); Publication No.: 10,821,156 (Publication Date: Nov 3, 2020).
• Implantable Devices Coated with Extracellular Matrix (Co-inventors: Klueh U, Kreutzer DL); Publication No.: 11,491,001 (Publication Date: Nov 8, 2022)
• Systems, Methods and Products for Minimizing Tissue Reactions and Tissue Injury at an Infusion Site (Co-inventors: Klueh U, Kreutzer DL); Publication No.: 11,554,160 (Publication Date: Jan 17, 2023)

Publications

Selected (past 3 years) 
Scopus URL

1. Kesserwan S, Sadagurski M, Mao L, Klueh U. Mast Cell Deficiency in Mice Attenuates Insulin Phenolic Preservative-Induced Inflammation. Biomedicines. 2023 Aug 12;11(8):2258. doi: 10.3390/biomedicines11082258. PMID: 37626754
2. Kesserwan S, Lewis BE, Mao L, Sharafieh R, Atwood T, Kreutzer DL, Klueh U. Inflammation at Site of Insulin Infusion Diminishes Glycemic Control. J Pharm Sci. 2022 Jul;111(7):1952-
3. Kesserwan S, Mao L, Sharafieh R, Kreutzer DL, Klueh U. A pharmacological approach assessing the role of mast cells in insulin infusion site inflammation. Drug Deliv Transl Res. 2022 Jul;12(7):1711-1718. doi: 10.1007/s13346-021-01070-w. PMID: 34561836
4. Lewis BE, Mulka A, Mao L, Sharafieh R, Qiao Y, Kesserwan S, Wu R, Kreutzer D, Klueh U. Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models. J Diabetes Sci Technol. 2023 Jan;17(1):163-171. doi: 10.1177/19322968211033868. PMID: 34286629
5. Mulka A, Lewis BE, Mao L, Sharafieh R, Kesserwan S, Wu R, Kreutzer DL, Klueh U. Phenolic Preservative Removal from Commercial Insulin Formulations Reduces Tissue Inflammation while Maintaining Euglycemia. ACS Pharmacol Transl Sci. 2021 Apr 26;4(3):1161-1174. doi: 10.1021/acsptsci.1c00047. eCollection 2021 Jun 11. PMID: 34151206
6. Elgebaly SA, Christenson RH, Kandil H, El-Khazragy N, Rashed L, Yacoub B, Eldeeb H, Ali M, Sharafieh R, Klueh U, Kreutzer DL. Nourin-Dependent miR-137 and miR-106b: Novel Early Inflammatory Diagnostic Biomarkers for Unstable Angina Patients. Biomolecules. 2021 Feb 28;11(3):368. doi: 10.3390/biom11030368. PMID: 33670982
7. Barr C, Sharafieh R, Schwarz G, Wu R, Klueh U, Kreutzer D. Noninflammatory Stress-Induced Remodeling of Mandibular Bone: Impact of Age and Pregnancy. J Oral Maxillofac Surg. 2021 May;79(5):1147-1155. doi: 10.1016/j.joms.2020.12.003. PMID: 33412113
8. Kesserwan S, Mulka A, Sharafieh R, Qiao Y, Wu R, Kreutzer DL, Klueh U. Advancing continuous subcutaneous insulin infusion in vivo: New insights into tissue challenges. J Biomed Mater Res A. 2021 Jul;109(7):1065-1079. doi: 10.1002/jbm.a.37097. PMID: 32896081
9. Didyuk O, Econom N, Guardia A, Livingston K, Klueh U. Continuous Glucose Monitoring Devices: Past, Present, and Future Focus on the History and Evolution of Technological Innovation. J Diabetes Sci Technol. 2021 May;15(3):676-683. doi: 10.1177/1932296819899394. PMID: 31931614

Education

• Doctor of Philosophy, Biomedical Engineering, University of Connecticut, School of Medicine, Farmington, CT
• Masters of Science, Chemical Engineering, University of Connecticut, Storrs, CT
• Bachelor of Science, Biotechnology, Fachhochschule Giessen-Friedberg (University of Applied Science), Germany

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