Bipradas Roy, Ph.D.

Bipradas Roy, Ph.D.

Bipradas Roy, Ph.D.

Position Title

Post Doctoral Trainee at Duke University


  1. Roy B, Runa SA. SARS-CoV-2 infection and diabetes: Pathophysiological mechanism of multi-system organ failure. World J Virol. 2022 Sep 25;11(5):252-274. doi: 10.5501/wjv.v11.i5.252. PMID: 36188734
  2. Pan G, Roy B, Giri S, Lanfear DE, Thandavarayan RA, Guha A, Ortiz PA, Palaniyandi SS. Aldehyde Dehydrogenase 2 Activator Augments the Beneficial Effects of Empagliflozin in Mice with Diabetes-Associated HFpEF. Int J Mol Sci. 2022 Sep 9;23(18):10439. doi: 10.3390/ijms231810439. PMID: 36142350
  3. Roy B, Pan G, Giri S, Thandavarayan RA, Palaniyandi SS. Aldehyde dehydrogenase 2 augments adiponectin signaling in coronary angiogenesis in HFpEF associated with diabetes. FASEB J. 2022 Aug;36(8):e22440. doi: 10.1096/fj.202200498R. PMID: 35815932
  4. Roy B, Yang Z, Pan G, Roth K, Agarwal M, Sharma R, Petriello MC, Palaniyandi SS. Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2. Toxics. 2022 Jun 16;10(6):328. doi: 10.3390/toxics10060328. PMID: 35736936
  5. Pan G, Roy B, Harding P, Lanigan T, Hilgarth R, Thandavarayan RA, Palaniyandi SS. Effects of intracardiac delivery of aldehyde dehydrogenase 2 gene in myocardial salvage. Gene Ther. 2022 May 24:10.1038/s41434-022-00345-2. doi: 10.1038/s41434-022-00345-2. PMID: 35606494
  6. Pan G, Roy B, Palaniyandi SS. Diabetic Aldehyde Dehydrogenase 2 Mutant (ALDH2*2) Mice Are More Susceptible to Cardiac Ischemic-Reperfusion Injury Due to 4-Hydroxy-2-Nonenal Induced Coronary Endothelial Cell Damage. J Am Heart Assoc. 2021 Sep 21;10(18):e021140. doi: 10.1161/JAHA.121.021140. Epub 2021 Sep 6. PMID: 34482710
  7. Roy B, Palaniyandi SS. Tissue-specific role and associated downstream signaling pathways of adiponectin. Cell Biosci. 2021 Apr 26;11(1):77. doi: 10.1186/s13578-021-00587-4. PMID: 33902691
  8. Roy B, Palaniyandi SS. A role for aldehyde dehydrogenase (ALDH) 2 in angiotensin II-mediated decrease in angiogenesis of coronary endothelial cells. Microvasc Res. 2021 Jan 8:104133. doi: 10.1016/j.mvr.2021.104133. PMID: 33428883
  9. Dham D, Roy B, Gowda A, Pan G, Sridhar A, Zeng X, Thandavarayan RA, Palaniyandi SS. 4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities. Free Radic Res. 2021 Jan 7:1-15. doi: 10.1080/10715762.2020.1866756. PMID: 33336611
  10. Roy B, Sundar K, Palaniyandi SS. 4-hydroxy-2-nonenal decreases coronary endothelial cell migration: Potentiation by aldehyde dehydrogenase 2 inhibition. Vascul Pharmacol. 2020 Jun 22:106762. doi: 10.1016/j.vph.2020.106762. PMID: 32585188
  11. Roy B, Palaniyandi SS. Aldehyde dehydrogenase 2 inhibition potentiates 4‐hydroxy‐2‐nonenal induced decrease in angiogenesis of coronary endothelial cells. Cell Biochem. & Function, accepted 11/11/19 DOI: 10.1002/cbf.3468
  12. Amara S, Majors C, Roy B, Hill S, Rose KL, Myles EL, Tiriveedhi V. Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation. PLoS One. 2017 Jun 28;12(6):e0180097. doi: 10.1371/journal.pone.0180097. eCollection 2017. PMID: 28658303 Free PMC Article
  13. Roy B, Curtis ME, Fears LS, Nahashon SN, Fentress HM. Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy. Front Physiol. 2016 Sep 29;7:439. eCollection 2016. Review. PMID: 27746742
  14. Roy B. Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures. World J Diabetes. 2013 Aug 15;4(4):101-13. doi: 10.4239/wjd.v4.i4.101. PMID: 23961320


Post Graduate Training

 2022-present Post Doctoral Fellow, Duke University, School of Medicine, Division of Cardiology


Suresh Palaniyandi, PhD

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