Wayne State University

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School of Medicine

Physiology

Andrew Butcko

Andrew Butcko

gq0373@wayne.edu

Andrew Butcko

Position Title

 PhD Candidate

Areas of Interest

 Functional Significance of PNPLA3 and the I148M Variant: Implications for Non-Alcoholic Fatty Liver Disease and Atherosclerosis

Publications

  1. Teskey G, Tiwari N, Butcko AJ, Kumar A, Yadav A, Huang YM, Kelly CV, Granneman JG, Perfield JW, Mottillo EP. Lipid droplet targeting of the lipase co-activator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis. J Biol Chem. 2025 Jan 13:108186. doi: 10.1016/j.jbc.2025.108186. PMID: 39814233
  2. Teskey G, Tiwari N, Butcko AJ, Kumar A, Yadav A, Huang YM, Kelly CV, Granneman JG, Perfield JW, Mottillo EP. Lipid droplet targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis. bioRxiv [Preprint]. 2024 Nov 15:2024.10.03.616525. doi: 10.1101/2024.10.03.616525. Update in: J Biol Chem. 2025 Jan 13:108186. doi: 10.1016/j.jbc.2025.108186. PMID: 39605541
  3. Harfmann BD, Bhaskaran S, Zubek J, Gordish K, Butcko A, Liu R, Vranish JR, Della-Moretta J, Westercamp CM, Chung CS, Elmer SJ. 11th Annual Michigan Physiological Society Meeting: June 24-25, 2024. Adv Physiol Educ. 2024 Dec 1;48(4):833-835. doi: 10.1152/advan.00167.2024. PMID: 39392686
  4. Butcko AJ, Putman AK, Mottillo EP. The intersection of genetic factors, aberrant nutrient metabolism and oxidative stress in the progression of cardiometabolic disease. Antioxidants 2024, 13, 87. https://doi.org/10.3390/antiox13010087
  5. Rahman AA, Butcko AJ, Songyekutu E, Granneman JG, Mottillo EP. Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. Sci Rep. 2024 Jan 2;14(1):19. doi: 10.1038/s41598-023-50903-w. PMID: 38167670
  6. Harfmann BD, Elmer SJ, Vranish JR, Bhaskaran S, Zubek JF, Gordish K, Butcko A, Westercamp CM, Bell HJ, Sharma N. 10th Annual Michigan Physiological Society Meeting: June 26-27, 2023. Adv Physiol Educ. 2023 Aug 10. doi: 10.1152/advan.00145.2023. PMID: 37560783

Education

BS in Exercise Science Kinesiology, Cental Michigan University

MS in Exercise Physiology, Central Michigan University

Advisor

Dr. Emilio Mottillo

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