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School of Medicine
Physiology
Nicholas Adzibolosu, Ph.D.

Nicholas Adzibolosu, Ph.D.

hc7424@wayne.edu

Nicholas Adzibolosu, Ph.D.

Position Title

Post Doc Fellow-University of Indiana School of Medicine

Areas of Interest

 Reproductive Science

Narrative Bio

I was a general medical practitioner for about three years prior to my current enrolment in Medical Sciences program at the Newcastle University in the UK in September 2019. Even though I have long been desirous of pursuing a career in the basic medical sciences (as I strongly believe that these form the bedrock upon which the future of medicine will be built), my three-year clinical experience has made my passion to pursue research and teaching in these sciences resolute. I encountered scores of pregnant women with various complications of pregnancy; the devastating ones being those who presented with severe pre-eclampsia or eclampsia. I still remember quite well the case of one woman who had developed a concealed placental abruption as a sequela of severe pre-eclampsia, leading to intrauterine fetal demise and subsequently disseminated intravascular coagulopathy. These experiences and memories motivate me constantly to strive to understand the mechanisms underlying the adverse cardiovascular events in pregnancy to enable me help improve on the existing treatment protocols and preferably introduce better preventive tools.

Publications

  1. Mor G, Singh A, Yang J, Adzibolosu N, Cai S, Kauf E, Yang L, Li Q, Li H, Werner A, Parthasarathy S, Ding J, Fortier J, Rodriguez-Garcia M, Diao LH. Decoding Functional and Developmental Trajectories of Tissue-Resident Uterine Dendritic Cells Through Integrative Omics. Res Sq [Preprint]. 2024 Nov 14:rs.3.rs-5424920. doi: 10.21203/rs.3.rs-5424920/v1. PMID: 39606471
  2. Wong TY, Adzibolosu NK, Mattei LH, Speak AC, Morris RT, Polan RM. Disparities in contemporary human papilloma virus vaccination uptake among adult women living in the United States: An All of Us Research Program study. Gynecol Oncol. 2024 Oct 8;191:100-105. doi: 10.1016/j.ygyno.2024.09.020. PMID: 39383630
  3. Chehade H, Gogoi R, Adzibolosu NK, Galoforo S, Fehmi RA, Kheil M, Fox A, Kim S, Rattan R, Hou Z, Morris RT, Matherly LH, Mor G, Alvero AB. BRCA status dictates Wnt responsiveness in epithelial ovarian cancer. Cancer Res Commun. 2024 Jul 19. doi: 10.1158/2767-9764.CRC-24-0111. PMID: 39028933
  4. Fox A, Leonard GD, Adzibolosu N, Wong T, Tedja R, Sharma S, Gogoi R, Morris R, Mor G, Fehl C, Alvero AB. Adipose microenvironment promotes hypersialylation of ovarian cancer cells. bioRxiv [Preprint]. 2024 May 15:2024.05.13.593990. doi: 10.1101/2024.05.13.593990. PMID: 38798490 PREPRINT
  5. Zhang Y, Tedja R, Millman M, Wong T, Fox A, Chehade H, Gershater M, Adzibolosu N, Gogoi R, Anderson M, Rutherford T, Zhang Z, Chopp M, Mor G, Alvero AB. Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells. bioRxiv. J Ovarian Res. 2023 Nov 30;16(1):233. doi: 10.1186/s13048-023-01312-0.PMID: 38037081
  6. Gogoi RP, Galoforo S, Fox A, Morris C, Ramos H, Gogoi VK, Chehade H, Adzibolosu NK, Shi C, Zhang J, Tedja R, Morris R, Alvero AB, Mor G. A Novel Role of Connective Tissue Growth Factor in the Regulation of the Epithelial Phenotype. Cancers (Basel). 2023 Oct 2;15(19):4834. doi: 10.3390/cancers15194834. PMID: 37835529
  7. Adzibolosu N, Alvero AB, Ali-Fehmi R, Gogoi R, Corey L, Tedja R, Chehade H, Gogoi V, Morris R, Anderson M, Vitko J, Lam C, Craig DB, Draghici S, Rutherford T, Mor G. Immunological modifications following chemotherapy are associated with delayed recurrence of ovarian cancer. Front. Immunol., 26 June 2023, Volume 14 – 2023, doi.org/10.3389/fimmu.2023.1204148
  8. Maxwell A, Adzibolosu N, Hu A, Stemmer PM, Ruden DM, Petriello MC, Sadagurski M, Debarba LK, Koshko L, Ramadoss J, Nguyen AT, Richards D, Liao A, Mor G, Ding J. Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure. iScience 26, 106287, April 21, 2023 doi.org/10.1016/j.isci.2023.106287
  9. Tedja R, Alvero AB, Fox A, Cardenas C, Pitruzzello M, Chehade H, Bawa T, Adzibolosu N, Gogoi R, Mor G. Generation of Stable Epithelial-Mesenchymal Hybrid Cancer Cells with Tumorigenic Potential. Cancers (Basel). 2023 Jan 22;15(3):684. doi: 10.3390/cancers15030684. PMID: 36765641
  10. Chehade H, Purandare N, Fox A, Adzibolosu N, Jayee S, Singh A, Tedja R, Gogoi R, Aras S, Grossman LI, Mor G, Alvero AB. MNRR1 is a driver of ovarian cancer progression. Transl Oncol. 2023 Jan 13;29:101623. doi: 10.1016/j.tranon.2023.101623. PMID: 36641875
  11. Chehade H, Tedja R, Ramos H, Bawa TS, Adzibolosu N, Gogoi R, Mor G, Alvero AB. Regulatory Role of the Adipose Microenvironment on Ovarian Cancer Progression. Cancers (Basel). 2022 May 1;14(9):2267. doi: 10.3390/cancers14092267. PMID: 35565396 Free PMC article. Review.
  12. Ding J, Maxwell A, Adzibolosu N, Hu A, You Y, Liao A, Mor G. Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon-stimulated genes signaling during pregnancy. Immunol Rev. 2022 Jul;308(1):9-24. doi: 10.1111/imr.13077. PMID: 35306673

Education

2025 Wayne State University, School of Medicine - PhD in Physiology (RPS concentration)

2020 Newcastle University - MS in Medical Science

2016 Kwame Nkruham University - MBBS

2013 Kwane Nkrumah University - B.Sc.

Advisor

Drs. Mor and Draghici

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