DCTP Sponsored Students

Timothy Bryson
Ph.D. Candidate
Mentor: Pamela Harding, Ph.D., & Robert Lasley, Ph.D.
Research: The balance between prostaglandin E2, EP3 and EP4 receptors determines severity of cardiac damage in an angiotensin II-induced model of hypertension

Publications:

  1. Bryson T, Gu X, Khalil RM, Khan S, Zhu L, Xu J, Peterson E, Yang XP, Harding P. Overexpression of Prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction. J Mol Cell Cardiol. 2018 Mar 6;118:1-12. doi: 10.1016/j.yjmcc.2018.03.005 PMID: 29522761
  2. Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, Harding P. Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Circulation:Heart Failure Circ Heart Fail. 2016 Aug;9(8). pii: e003291. PMID: 27502370
  3. Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X. COPII Dependent ER Export: a Critical Component of Insulin Biogenesis and Beta Cell ER Homeostasis. Mol Endocrinol. 2015 Jun 17:me20151012. PMID: 26083833.

Brianne Lewis
Ph.D. Candidate
Mentor:  Timothy Stemmler, Ph.D.
Research: A closer look at substances for Fe-S scaffold protein, Isu

Publications:

  1. Holcomb J, Doughan M, Spellmon N, Lewis B, Perry E, Zhang Y, Nico L, Wan J, Chakravarthy S, Shang W, Miao Q, Stemmler T, Yang Z. SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains. PLoS One. 2018 Jan 18;13(1):e0191371. doi: 10.1371/journal.pone.0191371. eCollection 2018. PMID: 29346419
  2. Ruetz M, Kumutima J, Lewis BE, Filipovic MR, Lehnert N, Stemmler TL, Banerjee R. A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin. J Biol Chem. 2017 Apr 21;292(16):6512-6528. doi: 10.1074/jbc.M116.770370. Epub 2017 Feb 28. PMID: 28246171
  3. Bostelaar T, Vitvitsky V, Kumutima J, Lewis BE, Yadav PK, Brunold TC, Filipovic M, Lehnert N, Stemmler TL, Banerjee R. Hydrogen Sulfide Oxidation by Myoglobin. J Am Chem Soc. 2016 Jul 13;138(27):8476-88. doi: 10.1021/jacs.6b03456. Epub 2016 Jun 30. PMID: 27310035 Free PMC Article
  4. Patel SJ, Lewis BE, Long JE, Nambi S, Sassetti CM, Stemmler TL, Argüello JM. Fine-tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases. J Biol Chem. 2016 May 27;291(22):11529-39. doi: 10.1074/jbc.M116.718239. Epub 2016 Mar 28. PMID: 27022029

Joseph Mannozzi
Ph.D. Candidate
Mentor:  Donal O'Leary, Ph.D.
Research: Relief of muscle metaboreflex vasoconstriction in heart failure by chronic ablation of skeletal muscle afferents
 


Cameron Pinnock (effective: August 17, 2018)
Ph.D. Candidate
Mentors: Mai Lam, Ph.D. and J.-P. Jin, M.D., Ph.D.
Research: In vitro atherosclerosis disease model via the ring stacking method

Publications:

  1. Patel B, Xu Z, Pinnock CB, Kabbani LS, Lam MT. Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts. Sci Rep. 2018 Feb 19;8(1):3294. doi: 10.1038/s41598-018-21681-7. PMID: 29459640 PMCID: PMC5818609
  2. Pinnock CB, Xu Z, Lam MT. Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method. J Vis Exp. 2017 Mar 27;(121). doi: 10.3791/5532 PMID: 28447994
  3. Pinnock CB, Meier EM, Joshi NN, Wu B, Lam MT. Customizable engineered blood vessels using 3D printed inserts. Methods. 2016 Apr 15;99:20-7. doi: 10.1016/j.ymeth.2015.12.015. Epub 2015 Dec 28. PMID: 26732049