DCTP Sponsored Students

Timothy Bryson
Ph.D. Candidate
Mentor: Pamela Harding, Ph.D., & Robert Lasley, Ph.D.
Research: The balance between prostaglandin E2, EP3 and EP4 receptors determines severity of cardiac damage in an angiotensin II-induced model of hypertension

Publications:

  1. Bryson T, Gu X, Khalil RM, Khan S, Zhu L, Xu J, Peterson E, Yang XP, Harding P. Overexpression of Prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction. J Mol Cell Cardiol. 2018 Mar 6;118:1-12. doi: 10.1016/j.yjmcc.2018.03.005 PMID: 29522761
  2. Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, Harding P. Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Circulation:Heart Failure Circ Heart Fail. 2016 Aug;9(8). pii: e003291. PMID: 27502370
  3. Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X. COPII Dependent ER Export: a Critical Component of Insulin Biogenesis and Beta Cell ER Homeostasis. Mol Endocrinol. 2015 Jun 17:me20151012. PMID: 26083833.

Brianne Lewis
Ph.D. Candidate
Mentor:  Timothy Stemmler, Ph.D.
Research: A closer look at substances for Fe-S scaffold protein, Isu

Publications:

  1. Kuhn ER, Naik AR, Lewis BE, Kokotovich KM, Li M, Stemmler TM, Larsson L, Jena BP. Nanothermometry Reveals Calcium-Induced Remodeling of Myosin ACS Nano Letters October 22, 2018, DOI: 10.1021/acs.nanolett.8b02989 (accepted)
  2. Holcomb J, Doughan M, Spellmon N, Lewis B, Perry E, Zhang Y, Nico L, Wan J, Chakravarthy S, Shang W, Miao Q, Stemmler T, Yang Z. SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains. PLoS One. 2018 Jan 18;13(1):e0191371. doi: 10.1371/journal.pone.0191371. eCollection 2018. PMID: 29346419
  3. Ruetz M, Kumutima J, Lewis BE, Filipovic MR, Lehnert N, Stemmler TL, Banerjee R. A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin. J Biol Chem. 2017 Apr 21;292(16):6512-6528. doi: 10.1074/jbc.M116.770370. Epub 2017 Feb 28. PMID: 28246171
  4. Bostelaar T, Vitvitsky V, Kumutima J, Lewis BE, Yadav PK, Brunold TC, Filipovic M, Lehnert N, Stemmler TL, Banerjee R. Hydrogen Sulfide Oxidation by Myoglobin. J Am Chem Soc. 2016 Jul 13;138(27):8476-88. doi: 10.1021/jacs.6b03456. Epub 2016 Jun 30. PMID: 27310035 Free PMC Article
  5. Patel SJ, Lewis BE, Long JE, Nambi S, Sassetti CM, Stemmler TL, Argüello JM. Fine-tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases. J Biol Chem. 2016 May 27;291(22):11529-39. doi: 10.1074/jbc.M116.718239. Epub 2016 Mar 28. PMID: 27022029

Joseph Mannozzi
Ph.D. Candidate
Mentor:  Donal O'Leary, Ph.D.
Research: Relief of muscle metaboreflex vasoconstriction in heart failure by chronic ablation of skeletal muscle afferents

Publications:

  1. Dombrowski M, Mannozzi J, O'Leary DS. Neural Control of Cardiovascular Function During Exercise in Hypertension. Front Physiol. 2018 Dec 20;9:1829. doi: 10.3389/fphys.2018.01829. eCollection 2018. Review. PMID: 30618837
  2. Mannozzi JT, Filbert VJ, Mackay WJ, Fulford DE, Steele CW. Evaluation of radiant catalytic ionization in reducing Escherichia coli, Listeria innocua and Salmonella typhimurium on representative food contact surfaces. The Texas Journal of Science, 70(1); 2018 (accepted) [undergraduate research project].

Cameron Pinnock (effective: August 17, 2018)
Ph.D. Candidate
Mentors: Mai Lam, Ph.D. and J.-P. Jin, M.D., Ph.D.
Research: In vitro atherosclerosis disease model via the ring stacking method

Publications:

  1. Xi J, Li M, Jing B, An M, Yu C, Pinnock C, Zhu Y, Lam M, Liu H. Long-Circulating Amphiphilic Doxorubicin for Tumor Mitochondria-Specific Targeting. ACS Appl Mater Interfaces. 2018 Nov 27. doi: 10.1021/acsami.8b17399. PMID: 30479120
  2. Patel B, Xu Z, Pinnock CB, Kabbani LS, Lam MT. Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts. Sci Rep. 2018 Feb 19;8(1):3294. doi: 10.1038/s41598-018-21681-7. PMID: 29459640 PMCID: PMC5818609
  3. Pinnock CB, Xu Z, Lam MT. Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method. J Vis Exp. 2017 Mar 27;(121). doi: 10.3791/5532 PMID: 28447994
  4. Pinnock CB, Meier EM, Joshi NN, Wu B, Lam MT. Customizable engineered blood vessels using 3D printed inserts. Methods. 2016 Apr 15;99:20-7. doi: 10.1016/j.ymeth.2015.12.015. Epub 2015 Dec 28. PMID: 26732049