DCTP Sponsored Students

Timothy Bryson
Ph.D. Candidate
Mentor: Pamela Harding, Ph.D., & Robert Lasley, Ph.D.
Research: The balance between prostaglandin E2, EP3 and EP4 receptors determines severity of cardiac damage in an angiotensin II-induced model of hypertension

Publications:

  1. Bryson T, Gu X, Khalil RM, Khan S, Zhu L, Xu J, Peterson E, Yang XP, Harding P. Overexpression of Prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction. J Mol Cell Cardiol. 2018 Mar 6;118:1-12. doi: 10.1016/j.yjmcc.2018.03.005 PMID: 29522761
  2. Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, Harding P. Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Circulation:Heart Failure Circ Heart Fail. 2016 Aug;9(8). pii: e003291. PMID: 27502370
  3. Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X. COPII Dependent ER Export: a Critical Component of Insulin Biogenesis and Beta Cell ER Homeostasis. Mol Endocrinol. 2015 Jun 17:me20151012. PMID: 26083833.

Matthew Fountain
Ph.D. Candidate
Mentor(s):  Glida Hillman, Ph.D. and J.-P. Jin, M.D., Ph.D.
Research: Mechanisms of Radioprotection by Soy Isoflavones: Modulations of Radiation-Induced Inflammatory and Oxidative Signaling Pathways

Publications:

  1. Dominello, MM*, Fountain, MD*, Rothstein, SE, Cannon AC, Abernathy LM, Hoogstra DJ, Chen, W, Joiner MC, and GG Hillman. Radiation injury to cardiac arteries and myocardium is reduced by soy isoflavones. Journal of Radiation Oncology First Online: 22 March 2017; DOI:10.1007/s13566-017-0301-z. *Denotes Co-first author
  2. Abernathy LM, Fountain MD, Joiner MC, and Hillman GG. Innate Immune Pathways Associated With Lung Radioprotection By Soy Isoflavones. Frontiers in Oncology, 2017, 7:7. PMID: 28168165 PMCID: PMC5253714 DOI: 0.3389/fonc.2017.00007.
  3. Hillman G, Reich, L, Fountain M, Rothstein S, Abernathy L, Hankerd K, Yunker C, Rakowski J, Quemeneur, Slos P. Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to tumor antigens. Journal for ImmunoTherapy of Cancer, 2017; 5:4. PMID: 28116088 PMCID: PMC5240430 DOI: 10.1186/s40425-016-0204-3. This article was highlighted by the Editor-in-Chief of the Journal for ImmunoTherapy of Cancer which is the journal of the Society for ImmunoTherapy of Cancer (January 18, 2017).
  4. Abernathy LM, Fountain MD, Rothstein SE, David JM, Yunker CK, Rakowski J, Lonardo F, Joiner MC, Hillman GG. Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced Activation of Macrophages and Neutrophils. Journal of Thoracic Oncology, 2015. 10: 1703-1712. PMC 26709479.
  5. Fountain MD, Abernathy LM, Lonardo F, Rothstein SE, Dominello MM, Yunker CK, Chen W, Gadgeel S, Joiner MC, Hillman GG. Radiation-Induced Esophagitis is Mitigated by Soy Isoflavones. Frontiers in Oncology, 2015; 5:238. PMCID: PMC4617099.

Brianne Lewis
Ph.D. Candidate
Mentor:  Timothy Stemmler, Ph.D.
Research: A closer look at substances for Fe-S scaffold protein, Isu

Publications:

  1. Holcomb J, Doughan M, Spellmon N, Lewis B, Perry E, Zhang Y, Nico L, Wan J, Chakravarthy S, Shang W, Miao Q, Stemmler T, Yang Z. SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains. PLoS One. 2018 Jan 18;13(1):e0191371. doi: 10.1371/journal.pone.0191371. eCollection 2018. PMID: 29346419
  2. Ruetz M, Kumutima J, Lewis BE, Filipovic MR, Lehnert N, Stemmler TL, Banerjee R. A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin. J Biol Chem. 2017 Apr 21;292(16):6512-6528. doi: 10.1074/jbc.M116.770370. Epub 2017 Feb 28. PMID: 28246171
  3. Bostelaar T, Vitvitsky V, Kumutima J, Lewis BE, Yadav PK, Brunold TC, Filipovic M, Lehnert N, Stemmler TL, Banerjee R. Hydrogen Sulfide Oxidation by Myoglobin. J Am Chem Soc. 2016 Jul 13;138(27):8476-88. doi: 10.1021/jacs.6b03456. Epub 2016 Jun 30. PMID: 27310035 Free PMC Article
  4. Patel SJ, Lewis BE, Long JE, Nambi S, Sassetti CM, Stemmler TL, Argüello JM. Fine-tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases. J Biol Chem. 2016 May 27;291(22):11529-39. doi: 10.1074/jbc.M116.718239. Epub 2016 Mar 28. PMID: 27022029

Joseph Mannozzi
Ph.D. Candidate
Mentor:  Donal O'Leary, Ph.D.
Research: Relief of muscle metaboreflex vasoconstriction in heart failure by chronic ablation of skeletal muscle afferents