School of Medicine

Wayne State University School of Medicine

Sponsored Students


Timothy Bryson
Ph.D. Candidate
Mentor:  Pamela Harding, Ph.D., & Steve Cala, Ph.D.
The balance between prostaglandin E2, EP3 and EP4 receptors determines severity of cardiac damage in an angiotensin II-induced model of hypertension


  1. Gu X, Xu J, Zhu L, Bryson T, Yang XP, Peterson E, Harding P. Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Circulation:Heart Failure Circ Heart Fail. 2016 Aug;9(8). pii: e003291. PMID: 27502370
  2. Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X. COPII Dependent ER Export: a Critical Component of Insulin Biogenesis and Beta Cell ER Homeostasis. Mol Endocrinol. 2015 Jun 17:me20151012. PMID: 26083833.

Joshua Holcomb
Ph.D. Candidate
Mentor(s):  Zhe Yang, Ph.D. and J.-P. Jin, M.D., Ph.D.
Structural and Functional Characterization of the Angiotensin-associated Nogo-B Receptor


  1. Jiang Y, Holcomb J, Spellmon N, Yang Z. Purification of Histone Lysine Methyltransferase SMYD2 and Co-Crystallization with a Target Peptide from Estrogen Receptor α. Methods Mol Biol. 2016;1366:207-17. PMID: 26585137
  2. Hou Y, Wu Y, Farooq SM, Guan X, Wang S, Liu Y, Oblak JJ, Holcomb J, Jiang Y, Strieter RM, Lasley RD, Arbab AS, Sun F, Li C, Yang Z. A critical role of CXCR2 PDZ-mediated interactions in endothelial progenitor cell homing and angiogenesis. Stem Cell Res. 2015 Mar;14(2):133-43. PMID: 25622052
  3. Spellmon N, Holcomb J, Trescott L, Sirinupong N, Yang Z. Structure and function of SET and MYND domain-containing proteins. Int J Mol Sci. 2015 Jan 8;16(1):1406-28. doi: 10.3390/ijms16011406. Review. PMID: 25580534
  4. Holcomb J, Spellmon N, Trescott L, Sun F, Li C, Yang Z. PDZ Structure and Implication in Selective Drug Design against Cystic Fibrosis. Curr Drug Targets. 2015;16(9):945-50. Review. PMID: 25523900
  5. Holcomb J, Jiang Y, Guan X, Trescott L, Lu G, Hou Y, Wang S, Brunzelle J, Sirinupong N, Li C, Yang Z. Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization. Biochem Biophys Res Commun. 2014 May 30;448(2):169-74. PMID: 24768637
  6. Holcomb J, Jiang Y, Lu G, Trescott L, Brunzelle J, Sirinupong N, Li C, Naren AP, Yang Z. Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation. Biochem Biophys Res Commun. 2014 Mar 28;446(1):399-403. PMID: 24613836
  7. JiangY, Holcomb J, Trescott L, Rice M, Yang Z. Structural Dissection of Cardiogenic and Myogenic SMYD Proteins. Experimental and clinical cardiology, Accepted, October 15, (2014).
  8. Trescott L, Holcomb J, Spellmon N, Mcleod C, Aljehane L, Sun F, Li C, Yang Z. Targeting the Root Cause of Cystic Fibrosis. Curr Drug Targets. 2015;16(9):933-44. Review. PMID: 25316272
  9. Jiang Y, Wang S, Holcomb J, Trescott L, Guan X, Hou Y, Brunzelle J, Sirinupong N, Li C, Yang Z. Crystallographic analysis of NHERF1-PLCβ3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer. Biochem Biophys Res Commun. 2014 Apr 4;446(2):638-43. PMID: 24642259
  10. Jiang Y, Trescott L, Holcomb J, Zhang X, Brunzelle J, Sirinupong N, Shi X, Yang Z. Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation. J Mol Biol. 2014 Oct 9;426(20):3413-25. PMID: 24594358
  11. Rice M, Jiang Y, Holcomb J, Trescott L, Spellmon N, Sirinupong N, Yang Z. SMYD2 Structure and Function: A Multispecificity Protein Lysine Methyltransferase. Journal of Cytology and Molecular Biology, 1(2):7, (2014).

Kevin Miles
Ph.D. Candidate
Mentor(s):  Howard Matthew, Ph.D. and TBA
Design of a Modular Endothelialized Platform for Bone Regeneration


  1. Miles KB, Ball RL, Matthew HW. Chitosan films with improved tensile strength and toughness from N-acetyl-cysteine mediated disulfide bonds. Carbohydr Polym. 2016 Mar 30;139:1-9. doi: 10.1016/j.carbpol.2015.11.052. PMID: 26794940