Publications-Physiology Faculty

January -  December 2019


Steve Cala, Ph.D.

  1. Solarewicz J, Manly A, Kokoszka S, Sleiman N, Leff T, Cala S. Adiponectin secretion from cardiomyocytes produces canonical multimers and partial co-localization with calsequestrin in junctional SR. Mol Cell Biochem. 2019 Jul;457(1-2):201-214. doi: 10.1007/s11010-019-03524-9. PMID: 30919218

Xuequn Chen, PhD

  1. Zhang L, Zhen J, Huang Q, Liu H, Li W, Zhang S, Min J, Li Y, Shi L, Woods J, Chen X, Shi Y, Liu Y, Hess RA, Song S, Zhang Z. Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein. Dev Dyn. 2019 Dec 9. doi: 10.1002/dvdy.141. PMID: 31816150
  2. Hou X, Wu Q, Rajagopalan C, Zhang C, Bouhamdan M, Wei H, Chen X, Zaman K, Li C, Sun X, Chen S, Frizzell RA, Sun F. CK19 stabilizes CFTR at the cell surface by limiting its endocytic pathway degradation. FASEB J. 2019 Aug 26:fj201901050R. doi: 10.1096/fj.201901050R. PMID: 31450978
  3. Naik AR, Kuhn ER, Lewis KT, Kokotovich KM, Maddipati KR, Chen X, Hörber JHK, Taatjes DJ, Potoff JJ, Jena BP. Self-Assembly and Biogenesis of the Cellular Membrane are Dictated by Membrane Stretch and Composition. J Phys Chem B. 2019 Jul 31. doi: 10.1021/acs.jpcb.9b04769. PMID: 31322890
  4. Zhu R, Li X, Xu J, Barrabi C, Kekulandara D, Woods J, Chen X, Liu M. Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells. Mol Cell Endocrinol. 2019 May 31:110470. doi: 10.1016/j.mce.2019.110470. PMID: 31158417
  5. Kim H, Williams D, Qiu Y, Song Z, Yang Z, Kimler V, Goldberg A, Zhang R, Yang Z, Chen X, Wang L, Fang D, Lin JD, Zhang K. Regulation of hepatic autophagy by stress-sensing transcription factor CREBH. FASEB J. 2019 Mar 26:fj201802528R. doi: 10.1096/fj.201802528R PMID: 30912978

Charles S. Chung, Ph.D.

  1. Milne ML, Schick BM, Alkhazal T, Chung CS. Myocardial Fiber Mapping of Rat Hearts, Using Apparent Backscatter, with Histologic Validation. Ultrasound Med Biol. 2019 May 30. pii: S0301-5629(19)30210-8. doi: 10.1016/j.ultrasmedbio.2019.05.002. PMID: 31155403
  2. Chung CS. How myofilament strain and strain rate lead the dance of the cardiac cycle. Arch Biochem Biophys. 2019 Jan 30. pii: S0003-9861(18)30685-4. doi: 10.1016/j.abb.2019.01.034. PMID: 30710504

Donald DeGracia, Ph.D.

  1. DeGracia DJ, Taha D, Tri Anggraini F, Huang ZF. Nonautonomous dynamics of acute cell injury. Phys. Rev. E 100, 052407 – Published 19 November 2019

Bhanu P. Jena, PhD

  1. Cacciani N, Salah H, Li M, Akkad H, Backeus A, Hedstrom Y, Jena BP, Bergquist J, Larsson L  Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model. Acta Physiol (Oxf). 2019 Dec 4:e13425. doi: 10.1111/apha.13425. PMID: 31799784
  2. Pernal, SP, Liyanaarachchi, A., Gatti DL., Formosa B., Pulvender R., Kuhn ER, Ramos R, Naik AR, George K, Arslanturk S, Taatjes DJ, Jena BP. (2019) Differential expansion  microscopy.  bioRxiv 699579; doi: https://doi.org/10.1101/699579
  3. Naik AR, Kuhn ER, Lewis KT, Kokotovich KM, Maddipati KR, Chen X, Hörber JHK, Taatjes DJ, Potoff JJ, Jena BP. Self-Assembly and Biogenesis of the Cellular Membrane are Dictated by Membrane Stretch and Composition. J Phys Chem B. 2019 Jul 31. doi: 10.1021/acs.jpcb.9b04769. PMID: 31322890
  4. Benjamins JA, Nedelkoska L, Touil H, Stemmer PM, Carruthers NJ, Jena BP, Naik AR, Bar-Or A, Lisak RP. Exosome-enriched fractions from MS B cells induce oligodendrocyte death. Neurol Neuroimmunol Neuroinflamm. 2019 Apr 9;6(3):e550. doi: 10.1212/NXI.0000000000000550. eCollection 2019 May. PMID: 31044144
  5. Jena BP, Gatti DL, Arslanturk S, Pernal S, Taatjes DJ. (2018) Human Skeletal Muscle Cell Atlas: Unraveling Cellular Secrets Utilizing 'Muscle-on-a-Chip', Differential Expansion Microscopy, Mass Spectrometry, Nanothermometry and Machine Learning. Micron. 2019 Feb;117:55-59. doi: 10.1016/j.micron.2018.11.002. PMID: 30472499  

J.P. Jin, MD, PhD

  1. Biesiadecki BJ, Brotto MA, Brotto LS, Koch LG, Britton SL, Nosek TM, Jin JP. Rats Genetically Selected for Low and High Aerobic Capacity Exhibit Altered Soleus Muscle Myofilament Functions.  Am J Physiol Cell Physiol. 2019 Dec 25. doi: 10.1152/ajpcell.00430.2019. PMID: 31875694
  2. Wong S, Feng HZ, Jin JP. The evolutionarily conserved C-terminal peptide of troponin I is an independently configured regulatory structure to function as a myofilament Ca2+-desensitizer. J Mol Cell Cardiol. 2019 Sep 7. pii: S0022-2828(19)30185-3. doi: 10.1016/j.yjmcc.2019.09.002. PMID: 31505197
  3. Feng HZ, Jin JP. Transgenic Expression of Carbonic Anhydrase III in Cardiac Muscle Demonstrates A Mechanism to Tolerate Acidosis. Am J Physiol Cell Physiol. 2019 Aug 7. doi: 10.1152/ajpcell.00130.2019. PMID: 31390226
  4. Plazyo O, Sheng JJ, Jin JP. Down-Regulation of Calponin 2 Contributes to the Quiescense of Lung Macrophages. Am J Physiol Cell Physiol. 2019 Jul 31. doi: 10.1152/ajpcell.00036.2019. PMID: 31365293
  5. Oki K, Wei B, Feng HZ, Jin JP . The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy. J Physiol. 2019 Aug;597(15):3999-4012. doi: 10.1113/JP278119 PMID: 31148174
  6. Biesiadecki BJ, Jin JP. Current and Future Directions of Myofilament Regulation. Arch Biochem Biophys. 2019 Apr 30;667:67-69. doi: 10.1016/j.abb.2019.04.011. [Epub ahead of print] PMID: 31051122
  7. Bagla S, Bhambhani K, Gadgeel M, Buck S, Jin JP, Ravindranath Y. Compound heterozygosity in PKLR gene for a previously unrecognized intronic polymorphism and a rare missense mutation as a novel cause of severe pyruvate kinase deficiency. Haematologica. 2019 Apr 4. pii: haematol.2018.214692. doi: 10.3324/haematol.2018.214692. PMID: 30948487
  8. Cao T, Thongam U, Jin JP. Invertebrate troponin: Insights into the evolution and regulation of striated muscle contraction. Arch Biochem Biophys. 2019 Mar 27;666:40-45. doi: 10.1016/j.abb.2019.03.013. PMID: 30928296
  9. Usacheva EA, Peterson LR, Mendoza K, Schora DM, Hossain MM, Jin JP. Cytoskeletal Tropomyosin as a Biomarker in Clostridium difficile Infection. J Clin Med Res. 2019 Feb;11(2):98-105. doi: 10.14740/jocmr3696. PMID: 30701001
  10. Feng HZ, Wang H, Takahashi K, Jin JP. Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. J Mol Cell Cardiol. 2019 Jan 29;129:49-57. doi: 10.1016/j.yjmcc.2019.01.026. PMID: 30707993

Jason H. Mateika, PhD

  1. Panza GS, Alex RM, Yokhana SS, Pioszak DS (Lee), Badr MS, Mateika JH. Increased oxidative stress, loop gain and the arousal threshold are clinical predictors of increased apnea severity following exposure to intermittent hypoxia. Nat Sci Sleep. 2019 Oct 24;11:265-279. doi: 10.2147/NSS.S228100. eCollection 2019. PMID: 31695534
  2. Mateika JH. A reminder that experimentally induced intermittent hypoxia is an incomplete model of OSA and its outcome measures. J Appl Physiol (1985). 2019 Dec 1;127(6):1620-1621. doi: 10.1152/japplphysiol.00549.2019. PMID: 31600097
  3. Mateika JH, Panza GS, Alex R, Castillo K. Pushing and pulling with no end in sight! The role of cross-talk between different forms of respiratory plasticity in modifying sleep apnoea. J Physiol. 2019 Jul 4. doi: 10.1113/JP278230. PMID: 31271221
  4. Alex RM, Panza GS, Hakim H, Badr MS, Edwards BA, Sands SA, Mateika JH. Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnoea. J Physiol. 2019 Apr 26. doi: 10.1113/JP277711. PMID: 31026056
  5. Mateika JH, Komnenov D, Pop A, Kuhn DM. Genetic depletion of 5-HT increases central apnea frequency and duration and dampens arousal but does not impact the circadian modulation of these variables. J Appl Physiol (1985). 2019 Jan 1;126(1):1-10. doi: 10.1152/japplphysiol.00724.2018. Epub 2018 Oct 18. PMID: 30335578

Patrick J. Mueller, PhD

  1. Mueller PJ, Fyk-Kolodziej BE, Azar TA, Llewellyn-Smith IJ. Subregional Differences in GABAA Receptor Subunit Expression in the Rostral Ventrolateral Medulla of Sedentary Versus Physically Active Rats. J Comp Neurol. 2019 Oct 22. doi: 10.1002/cne.24798. PMID: 31642070

Donal S. O'Leary, PhD

  1. Cristina-Oliveira M, Meireles K, Spranger MD, O'Leary DS, Roschel H, Peçanha T. Clinical safety of blood flow restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise. Am J Physiol Heart Circ Physiol. 2019 Nov 8. doi: 10.1152/ajpheart.00468.2019. PMID: 31702969
  2. Reynolds C, O'Leary DS, Ly C, Smith SA, Minic Z. Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat. Am J Physiol Heart Circ Physiol. 2019 Mar 15. doi: 10.1152/ajpheart.00724.2018. PMID: 30875256
  3. O'Leary DS, Senador D, Augustyniak RA. Muscle Metaboreflex - Induced Central Blood Volume Mobilization in Heart Failure. Am J Physiol Heart Circ Physiol. 2019 Mar 1. doi: 10.1152/ajpheart.00805.2018. PMID: 30822120

Karin Przyklenk, PhD

  1. Wider JM, Przyklenk K. Cardioprotection with Ischemic Conditioning: The Diabetes Dilemma. Conditioning Medicine, 2(1):10-17, Feb 2019.
  2. Przyklenk K. Journal of Cardiovascular Pharmacology and Therapeutics: Expanding the Legacy. J Cardiovasc Pharmacol Ther. 2019 Jul;24(4):303. doi: 10.1177/1074248419852228. PMID: 31170824
  3. Strubakos CD, Malik M, Wider JM, Lee I, Reynolds CA, Mitsias P, Przyklenk K, Hüttemann M, Sanderson TH  Non-invasive treatment with near-infrared light: A novel mechanisms-based strategy that evokes sustained reduction in brain injury after stroke. J Cereb Blood Flow Metab. 2019 May 21:271678X19845149. doi: 10.1177/0271678X19845149. PMID: 31112450
  4. Sprick JD, Mallet RT, Przyklenk K, Rickards CA. Ischaemic and hypoxic conditioning: potential for protection of vital organs. Exp Physiol. 2019 Mar;104(3):278-294. doi: 10.1113/EP087122. PMID: 30597638

Jeff L. Ram, PhD

  1. Cangelosi AA, Balcer M, Reavie ED, Ram JL (2019) Ballast Management in the Great Lakes: Priorities and Technologies for Indicative Testing. Lansing, MI: Qubic Marketing Agency, 40 pages.
  2. AG Boegehold, NS Johnson, JL Ram, DR Kashian  Cyanobacteria reduce quagga mussel (Dreissena rostriformis bugensis) spawning and fertilization success Freshwater Science 37 (3), 510-518

Noreen F. Rossi, MD

  1. Levanovich PE, Diaczok A, Rossi NF. Clinical and Molecular Perspectives of Monogenic Hypertension. Curr Hypertens Rev. 2019 Apr 9. doi: 10.2174/1573402115666190409115330. PMID: 30963979
  2. Komnenov D, Levanovich PE, Rossi NF. Hypertension Associated with Fructose and High Salt: Renal and Sympathetic Mechanisms. Nutrients. 2019 Mar 7;11(3). pii: E569. doi: 10.3390/nu11030569. PMID: 30866441
  3. Rossi NF, Zenner Z, Rishi AK, Levi E, Maliszewska-Scislo M. AT1 Receptors in the Subfornical Organ Modulate Arterial Pressure and the Baroreflex In Two-kidney One-clip Hypertensive Rats. Am J Physiol Regul Integr Comp Physiol. 2019 Jan 9. doi: 10.1152/ajpregu.00289.2018. [PMID: 30624974

Assia Shisheva, Ph.D.

  1. Ikonomov OC, Sbrissa D, Shisheva A. Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations. Toxicol Appl Pharmacol. 383, 114771. 2019 Oct 15:114771. doi: 10.1016/j.taap.2019.114771. [PMID: 31628917
  2. Shisheva A, Sbrissa D, Hu B, Li J. Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J. Mol Neurobiol. 2019 Jul 16. Dec 2019, 56:8656 – 8667; doi: 10.1007/s12035-019-01693-8. PMID: 31313076
  3. Sbrissa D, Semaan L, Govindarajan B, Li Y, Caruthers NJ, Stemmer PM, Cher ML, Sethi S, Vaishampayan U, Shisheva A, Chinni SR. A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells. Oncogene. 2019 Jan;38(3):332-344. doi: 10.1038/s41388-018-0448-0. PMID: 30111818

Fei Sun, PhD

  1. Zaman K, Knight J, Hussain F, Cao R, Estabrooks SK, Altawallbeh G, Holloway K, Jafri A, Sawczak V, Li Y, Getsy P, Sun F, Raffay T, Cotton C, Brodsky JL, Periasamy A, Lewis SJ, Gaston B. S-Nitrosylation of CHIP Enhances F508Del CFTR Maturation. Am J Respir Cell Mol Biol. 2019 Oct 9. doi: 10.1165/rcmb.2018-0314OC. [PMID: 31596601
  2. Hou X, Wu Q, Rajagopalan C, Zhang C, Bouhamdan M, Wei H, Chen X, Zaman K, Li C, Sun X, Chen S, Frizzell RA, Sun F. CK19 stabilizes CFTR at the cell surface by limiting its endocytic pathway degradation. FASEB J. 2019 Aug 26:fj201901050R. doi: 10.1096/fj.201901050R. PMID: 31450978
  3. Yang J, Long Y, Xu DM, Zhu BL, Deng XJ, Yan Z, Sun F, Chen GJ. Age- and Nicotine-Associated Gene Expression Changes in the Hippocampus of APP/PS1 Mice. J Mol Neurosci. 2019 Aug 10. doi: 10.1007/s12031-019-01389-7. PMID: 31399937
  4. Lai YJ, Zhu BL, Sun F, Luo D, Ma YL, Luo B, Tang J, Xiong MJ, Liu L, Long Y, Hu XT, He L, Deng XJ, Zhang JH, Yang J, Yan Z, Chen GJ  Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019 Apr 22:e12961. doi: 10.1111/acel.12961. PMID: 31012223
  5. Ruan J, Hirai H, Yang D, Ma L, Hou X, Jiang H, Wei H, Rajagopalan C, Mou H, Wang G, Zhang J, Li K, Chen YE, Sun F, Xu J. Efficient Gene Editing at Major CFTR Mutation Loci. Mol Ther Nucleic Acids. 2019 Feb 16;16:73-81. doi: 10.1016/j.omtn.2019.02.006. PMID: 30852378
  6. Zhu BL, Long Y, Luo W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ, Wang XF, Sun F, Chen GJ. MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation. Brain. 2019 Jan 1;142(1):176-192. doi: 10.1093/brain/awy305. PMID: 30596903
  7. Wang H, Ju D, Kho DH, Yang H, Li L, Raz A, Sun F, Xie Y. The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation. Biochem Biophys Res Commun. 2019 Feb 5;509(2):348-353. doi: 10.1016/j.bbrc.2018.12.141 PMID: 30585151

Robert J. Wessells, Ph.D.

  1. Xu P, Damschroder D, Zhang M, Ryall KA, Adler PN, Saucerman JJ, Wessells RJ, Yan Z. Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila. J Mol Cell Cardiol. 2019 Feb;127:116-124. doi: 10.1016/j.yjmcc.2018.12.006. PMID: 30571977
  2. Sujkowski A, Spierer AN, Rajagopalan T, Bazzell B, Safdar M, Imsirovic D, Arking R, Rand DM, Wessells R. Mito-nuclear interactions modify Drosophila exercise performance. Mitochondrion. 2019 Jul;47:188-205. doi: 10.1016/j.mito.2018.11.005. Epub 2018 Nov 6. PMID: 30408593

Zhibing Zhang, PhD

  1. Zhang L, Zhen J, Huang Q, Liu H, Li W, Zhang S, Min J, Li Y, Shi L, Woods J, Chen X, Shi Y, Liu Y, Hess RA, Song S, Zhang Z. Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein. Dev Dyn. 2019 Dec 9. doi: 10.1002/dvdy.141. PMID: 31816150
  2. Wang Z, Shi Y, Ma S, Huang Q, Yap YT, Shi L, Zhang S, Zhou T, Li W, Hu B, Zhang L, Krawetz SA, Pazour GJ, Hess RA, Zhang Z. Abnormal fertility, acrosome formation, IFT20 expression and localization in the conditional Gmap210 knockout mice. Am J Physiol Cell Physiol. 2019 Oct 2. doi: 10.1152/ajpcell.00517.2018. PMID: 31577511
  3. Xiong W, Zhang L, Liu H, Li N, Du Y, He H, Zhang Z, Liu Y. E2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis. J Cell Mol Med. 2019 Sep 27. doi: 10.1111/jcmm.14668. PMID: 31560827
  4. Huang Q, Liu H, Zeng J, Li W, Zhang S, Zhang L, Song S, Zhou T, Sutoysky M, Sutoysky P, Pardi R, Hess RA, Zhang Z. COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis. Biol Reprod. 2019 Aug 2. pii: ioz154. doi: 10.1093/biolre/ioz154. PMID: 31373619
  5. Liu Y, Zhang L, Li W, Huang Q, Yuan S, Li Y, Liu J, Zhang S, Pin G, Song S, Ray PF, Arnoult C, Cho C, Garcia-Reyes B, Knippschild U, Strauss Iii JF, Zhang Z. The sperm associated antigen 6 interactome and its role in spermatogenesis. Reproduction. 2019 May 1. pii: REP-18-0522.R1. doi: 10.1530/REP-18-0522. PMID: 31146259
  6. Shi L, Zhou T, Huang Q, Zhang S, Li W, Zhang L, Hess RA, Pazour GJ, Zhang Z. Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in mice‡. Biol Reprod. 2019 Apr 20. pii: ioz071. doi: 10.1093/biolre/ioz071. PMID: 31004481
  7. Zhang Z, Huang Q, Wang Z, Zou J, Yu Z, Strauss JF, Zhang Z. Elongin B is a binding partner of the male germ cell nuclear speckle protein sperm-associated antigen 16S (SPAG16S) and is regulated post-transcriptionally in the testis. Reprod Fertil Dev. 2019 Feb 28. doi: 10.1071/RD18303 PMID: 30811962