Wayne State University

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School of Medicine

Physiology

DCTP Sponsored Students

Andrew Butcko

PhD. Candidate in Physiology
Mentors:  Emilio Mottillo, PhD
Research: Functional Significance of PNPLA3 and the I148M Variant: Implications for Non-Alcoholic Fatty Liver Disease and Atherosclerosis

Publications:

  1. Butcko AJ, Putman AK, Mottillo EP. The intersection of genetic factors, aberrant nutrient metabolism and oxidative stress in the progression of cardiometabolic disease. Antioxidants 2024, 13, 87. https://doi.org/10.3390/antiox13010087
  2. Rahman AA, Butcko AJ, Songyekutu E, Granneman JG, Mottillo EP. Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. Sci Rep. 2024 Jan 2;14(1):19. doi: 10.1038/s41598-023-50903-w. PMID: 38167670
  3. Harfmann BD, Elmer SJ, Vranish JR, Bhaskaran S, Zubek JF, Gordish K, Butcko A, Westercamp CM, Bell HJ, Sharma N. 10th Annual Michigan Physiological Society Meeting: June 26-27, 2023. Adv Physiol Educ. 2023 Aug 10. doi: 10.1152/advan.00145.2023. PMID: 37560783

Maryam Safdar

MD/PhD. - Candidate in Physiology
Mentors:  Robert Wessells, PhD
Research: Endurance exercise as a rescue for negative health outcomes resulting from circadian rhythm disturbances in Drosophila

Publications:

  1. Safdar M, Wessells R. Octopamine Rescues Endurance and Climbing Speed in Drosophila Clkout Mutants with Circadian Rhythm Disruption. Cells 2023, 12(21), 2515; https://doi.org/10.3390/cells12212515
  2. Cobb T, Hwang I, Soukar M, Namkoong S, Cho US, Safdar M, Kim M, Wessells RJ, Jun Hee Lee JH. Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy. Proc Natl Acad Sci. 2023 Sep 26;120(39):e2220556120. doi: 10.1073/pnas.2220556120.
  3. Ahmed S, Safdar M, Morton C, Soave N, Patel R, Castillo K, Lalande S, Jimenez L, Mateika JH, Wessells R. Effect of virtual reality-simulated exercise on sympathovagal balance. PLoS One. 2020 Jul 16;15(7):e0235792. doi: 10.1371/journal.pone.0235792. PMID: 32673347
  4. Sujkowski A, Spierer AN, Rajagopalan T, Bazzell B, Safdar M, Imsirovic D, Arking R, Rand DM, Wessells R. Mito-nuclear interactions modify Drosophila exercise performance. Mitochondrion. 2019 Jul;47:188-205. doi: 10.1016/j.mito.2018.11.005. PMID: 30408593