Wayne State University

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School of Medicine

Physiology

DCTP Sponsored Students

Noah Gleason

Ph.D. Candidate in Pharmaceutical Science
Mentor: Anjaneyulu Kowluru, Ph.D./Xuequn Chen, Ph.D.
Research: RhoGDI-Rho G protein cross talk in the pancreatic β cell under metabolic stress

Publications:

  1. Gleason N, Williams CL, Kowluru A. Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells. Mol Cell Endocrinol. 2023 Oct 30:112104. doi: 10.1016/j.mce.2023.112104. PMID: 38013223
  2. Kowluru A, Gamage S, Hali M, Gleason N. Hyperglycemic Conditions Promote Rac1-Mediated Serine536 Phosphorylation of p65 Subunit of NFκB (RelA) in Pancreatic Beta Cells. Cell Physiol Biochem. 2022 Aug 19;56(4):367-381. doi: 10.33594/000000557. PMID: 35981264
  3. Kowluru A, Gleason NF. Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochem Pharmacol. 2022 Mar;197:114886. doi: 10.1016/j.bcp.2021.114886. PMID: 34968495 Review.
  4. Hinton TV, Batelu S, Gleason N, Stemmler TL. Molecular characteristics of proteins within the mitochondrial Fe-S cluster assembly complex. Micron. 2022 Feb;153:103181. doi: 10.1016/j.micron.2021.103181. PMID: 34823116 Review.
  5. Chundru SA, Harajli A, Hali M, Gleason N, Gamage S, Kowluru A. RhoG-Rac1 Signaling Pathway Mediates Metabolic Dysfunction of the Pancreatic Beta-Cells Under Chronic Hyperglycemic Conditions. Cell Physiol Biochem. 2021 Apr 14;55(2):180-192. doi: 10.33594/000000354. PMID: 33851799

Lukas Stilgenbauer

PhD. Candidate in Biomedical Sciences
Mentors:  Marianna Sadagurski, Ph.D. and KeZhong Zhang, Ph.D.
Research: Defining the role of ER stress driven neuroinflammation

Publications:

  1. Koshko L, Scofield S, Debarba L, Stilgenbauer L, Fakhoury P, Jayarathne H, Perez-Mojica JE, Griggs E, Lempradl A, Sadagurski M. Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life. Chemosphere. 2023 Jul;330:138738. doi: 10.1016/j.chemosphere.2023.138738. PMID: 37084897
  2. Adelabu I, Chowdhury MRH, Nantogma S, Oladun C, Ahmed F, Stilgenbauer L, Sadagurski M, Theis T, Goodson BM, Chekmenev EY. Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate. Metabolites. 2023 Jan 29;13(2):200. doi: 10.3390/metabo13020200. PMID: 36837820
  3. Koshko L, Scofield S, Debarba L, Stilgenbauer L, Sacla M, Fakhoury P, Jayarathne H, Perez-Mojica JE, Griggs E, Lempradl A, Sadagurski M. Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life. bioRxiv. 2023 Jan 5:2023.01.05.522910. doi: 10.1101/2023.01.05.522910. Preprint. PMID: 36711607
  4. Stilgenbauer L, de Lima JBM, Debarba LK, Khan M, Koshko L, Kopchick JJ, Bartke A, Schneider A, Sadagurski M. Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner. Geroscience. 2023 Jan 12. doi: 10.1007/s11357-023-00726-4. PMID: 36633824
  5. Ye CJ, Stilgenbauer L, Moy A, Liu G, Heng HH. What Is Karyotype Coding and Why Is Genomic Topology Important for Cancer and Evolution? Front Genet. 2019 Nov 1;10:1082. doi: 10.3389/fgene.2019.01082. eCollection 2019. PMID: 31737054

Sara Syeda

PhD. Candidate in Economics
Mentors:  Shooshan Danagoulian, Ph.D. and Phil Levy, M.D.
Research: Effects of Air Pollution on Mother and Infant Health in Wayne County

Publications:

  1. Ramsey T, Guo E, Svider PF, Lin H, Syeda S, Raza SN, Fribley AM. Laryngeal cancer: Global socioeconomic trends in disease burden and smoking habits. Laryngoscope. 2018 Sep;128(9):2039-2053. doi: 10.1002/lary.27068. PMID: 29508408

Rafael Ramos

PhD. Candidate in Chemical Engineering
Mentors:  Howard Matthew, PhD
Research: Modular Bioprinting Assembly of Transplantable Liver Tissue

Publications:

  1. Moses, T.E., Chammaa, M., Ramos, R., Waineo, E. and Greenwald, M.K.; Opioid Overdose Prevention and Response Training for First Year Medical Students: Does training provide a benefit outside of the traditional curriculum? Substance Abuse {Under Review}
  2. Moses TE, Chammaa M, Ramos R, Waineo E, Greenwald MK. Incoming medical students' knowledge of and attitudes toward people with substance use disorders: Implications for curricular training. Subst Abus. 2021;42(4):692-698. doi: 10.1080/08897077.2020.1843104. Epub 2020 Nov 9. PMID: 33166242
  3. Laethem, B.S., Lewis, K.T., Ramos, R., Hou, X., Sun, F., Taatjes, D.J., Jena, B.P. and Arslanturk, S., 2020. Cystic fibrosis transmembrane conductance regulator (CFTR) inhibition results in mucus accumulation in human airway epithelia Calu-3 cells: Experimental and Machine Learning Studies. BioRxiv
  4. Ma H, Hu J, Tian J, Zhou X, Li H, Laws MT, Wesemann LD, Zhu B, Chen W, Ramos R, Xia J, Shao J. A single-center, retrospective study of COVID-19 features in children: a descriptive investigation. BMC Med. 2020 May 6;18(1):123. doi: 10.1186/s12916-020-01596-9. PMID: 32370747
  5. Pernal, S.P., Liyanaarachchi, A., Gatti, D.L., Formosa, B., Pulvender, R., Kuhn, E.R., Ramos, R., Naik, A.R., George, K., Arslanturk, S. and Taatjes, D.J., 2020. Nanoscale imaging using differential expansion microscopy. Histochemistry and Cell Biology, pp.1-12
  6. Freeman S, Ramos R, Alexis Chando P, Zhou L, Reeser K, Jin S, Soman P, Ye K. A bioink blend for rotary 3D bioprinting tissue engineered small-diameter vascular constructs. Acta Biomater. 2019 Sep 1;95:152-164. doi: 10.1016/j.actbio.2019.06.052. Epub 2019 Jul 2. PMID: 31271883
  7. Ramos R, Zhang K, Quinn D, Sawyer SW, Mcloughlin S, Soman P. Measuring Changes in Electrical Impedance During Cell-Mediated Mineralization. Bioelectricity. 2019 Jun 1;1(2):73-84. doi: 10.1089/bioe.2018.0008. Epub 2019 Jun 14. PMID: 34471812 Free PMC article.
  8. Xiong Z, Li H, Kunwar P, Zhu Y, Ramos R, Mcloughlin S, Winston T, Ma Z, Soman P. Femtosecond laser induced densification within cell-laden hydrogels results in cellular alignment. Biofabrication. 2019 Apr 5;11(3):035005. doi: 10.1088/1758-5090/ab0f8b. PMID: 30865942
  9. Winston TS, Suddhapas K, Wang C, Ramos R, Soman P, Ma Z.  Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells. Stem Cells Int. 2019 Jan 15;2019:5654324. doi: 10.1155/2019/5654324. eCollection 2019. PMID: 30766604

Andrew Butcko

PhD. Candidate in Physiology
Mentors:  Emilio Mottillo, PhD
Research: Functional Significance of PNPLA3 and the I148M Variant: Implications for Non-Alcoholic Fatty Liver Disease and Atherosclerosis

Publications:

Maryam Safdar

MD/PhD. - Candidate in Physiology
Mentors:  Robert Wessells, PhD
Research: Endurance exercise as a rescue for negative health outcomes resulting from circadian rhythm disturbances in Drosophila

Publications:

  1. Safdar M, Wessells R. Octopamine Rescues Endurance and Climbing Speed in Drosophila Clkout Mutants with Circadian Rhythm Disruption. Cells 2023, 12(21), 2515; https://doi.org/10.3390/cells12212515
  2. Cobb T, Hwang I, Soukar M, Namkoong S, Cho US, Safdar M, Kim M, Wessells RJ, Jun Hee Lee JH. Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy. Proc Natl Acad Sci. 2023 Sep 26;120(39):e2220556120. doi: 10.1073/pnas.2220556120.
  3. Ahmed S, Safdar M, Morton C, Soave N, Patel R, Castillo K, Lalande S, Jimenez L, Mateika JH, Wessells R. Effect of virtual reality-simulated exercise on sympathovagal balance. PLoS One. 2020 Jul 16;15(7):e0235792. doi: 10.1371/journal.pone.0235792. PMID: 32673347
  4. Sujkowski A, Spierer AN, Rajagopalan T, Bazzell B, Safdar M, Imsirovic D, Arking R, Rand DM, Wessells R. Mito-nuclear interactions modify Drosophila exercise performance. Mitochondrion. 2019 Jul;47:188-205. doi: 10.1016/j.mito.2018.11.005. PMID: 30408593